Mass spectrometry for multiplexed high throughput analysis of large molecules

Whether it is for research, development or diagnostics, life sciences typically require the quantitation and characterization of samples with assays that classically measure molecules one at a time. Considering that the development and execution of such assays are time consuming and requires considerable investment, the uses of multiplexed analysis would be highly advantageous. Mass spectrometry is a technology that allows multiplexing, but requires highly specialized knowledge in order to achieve the desired results. It is not new that large molecules, mostly proteins, are being analyzed by mass spectrometry. However it remains limited to literate users due to the complexity of the task. Using state-of-the-art instrumentation, this project aims to develop highly standardized approach with simplified data analysis to break barriers that limit the use of mass spectrometry for large molecules analysis. The result of this research will lead to the deployment of services that will reduce cost, accelerate and simplify complex sample characterization in life sciences.

Faculty Supervisor:

Dr. Klaus Klarskov

Student:

Hugo Gagnon

Partner:

PhenoSwitch Biosciences Inc.

Discipline:

Biochemistry / Molecular biology

Sector:

Life sciences

University:

Université de Sherbrooke