Measuring the forces involved in cancer cells migration in vitro

What makes cancer so lethal is the ability of tumor cells to migrate from one organ to another through the blood circulation. Typically, cancer cells first detach from primary tumors, and then enter the blood vessels to be carried over long distances. At the target site, the tumor cells attack the blood vessel walls cover by endothelial cells to create a gap through which they can escape into the surrounding tissues and organs. My research deals with the last phase of this process, the so-called trans-endothelial migration (TEM). The novelty of my approach is to explore the connection and coupling between biochemical signaling and mechanical forces that determine cell deformation and movement. For this purpose, I will combine experimental measurements with computer simulations to elucidate the factors that enable the success of TEM, and to seek strategies to disrupt it.

Faculty Supervisor:

James J Feng

Student:

Partner:

Université Grenoble Alpes

Discipline:

Engineering

Sector:

Education

University:

The University of British Columbia

Program: