Mechanistic Analysis of Cross-Coupling Reactions

Palladium-catalyzed cross coupling is one of the most powerful tools in modern synthetic chemistry, with is collaborative discovery recognised with the 2010 Nobel Prize for Chemistry. This class of reactions has had a huge impact on the way in which chemists think about building fine chemicals, because it allows for clipping of two molecules together to make a more elaborate one under mild reaction conditions. Despite its popularity in use, these catalysts have a mechanism and nature of the catalytically relevant species that is incompletely understood. We plan to combine our expertise to probe key mechanistic questions in palladium-catalyzed cross coupling reactions focusing on the catalyst activation process. This collaboration is aimed at building up a robust model of the chemistry and generate actionable recommendations for rational improvement of reaction protocols that identify areas for improvement, reduce catalyst consumption, and better utilize this precious earth resource.

Faculty Supervisor:

J. Scott McIndoe

Student:

Partner:

University of York

Discipline:

Physics

Sector:

Pharmaceuticals; Sustainability & the Environment; Clean Technology

University:

University of Victoria

Program: