Next-Generation Wound Dressings: MOF-Loaded 3D-Printed Hydrogels for Diabetic Ulcer Treatment

Diabetic foot ulcers are a major complication of diabetes, often leading to serious infections and even limb amputations. These chronic wounds heal poorly due to prolonged inflammation, oxidative stress, and tissue damage. This project aims to develop an advanced wound dressing that combines natural and synthetic materials with innovative nanotechnology to improve healing outcomes. The dressing is based on a hydrogel made from Furcellaran (a seaweed-derived polymer), poly(vinyl alcohol), and glycerol. This formulation supports moisture retention, flexibility, and cell growth. To enhance its healing power, the hydrogel will be embedded with nanozymes—tiny, enzyme-like metal-organic frameworks (MOFs) that can reduce oxidative stress and fight bacteria. Using 3D printing, the dressing can be customized to fit irregular wounds, offering precise and effective treatment. The goal is to accelerate healing, reduce infection risk, and lower healthcare costs for diabetic patients. This international collaboration brings together CEITEC Brno University of Technology and the University of Waterloo. CEITEC focuses on hydrogel development, while Waterloo contributes expertise in nanomaterials and biological testing. The project not only addresses a critical medical need but also supports global goals for health innovation, sustainability, and interdisciplinary research.

Faculty Supervisor:

Milad Kamkar

Student:

Partner:

Brno University of Technology

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

University of Waterloo

Program: