Optimization of Bull Semen Cryopreservation through Iterative and Rational Media Design

Cryopreserved (frozen) semen provides optimal genetics to cattle and especially dairy farmers, facilitating improved breeding programs. The sperm cryopreservation process significantly reduces fertility compared to fresh sperm. Each percent of reduced fertility amounts to a significant financial loss to farmers. Thus there is great pressure on semen providers to improve post thaw fertility, as it is a significant market decider. In order to be successfully cryopreserved, sperm must undergo a number of damaging processes. Many previous researchers have looked at specific processes individually, but we believe that all parts of the cryopreservation process must be considered in an interconnected whole. Therefore, we propose a novel whole-protocol optimization strategy combining novel biophysical research with a novel experimental optimization design. This will result in an improved sperm cryopreservation protocol for SEMEX, and improved understanding of sperm damage so that well designed follow-up studies can be implemented.

Faculty Supervisor:

James Benson


Maajid Bhat


L'Alliance Boviteq








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