Redox-dependent mechanisms of the innate immune antiviral response

The molecular mechanisms that explain how the host triggers a first antiviral response against virus infection has been the focus of numerous studies over the past decades. This first line of response involves key signaling cascades that permit the expression of antiviral and proinflammatory genes. Recently we have demonstrated that the production of reactive oxygen species (ROS) plays a key role in the regulation of this response. These molecules are often associated with damage, but they are now well known to play a key role in the regulation of signaling events through oxidation of proteins. Having characterized the contribution of ROS to the innate antiviral response, we are now seeking to identify the proteins that are regulated by oxidation during this response. The project will involve culture of human cell lines and state-of-the art biochemistry and cellular biology techniques.

Faculty Supervisor:

Nathalie Grandvaux

Student:

CYNTHIA ALEJANDRA PAZ TREJO

Partner:

Discipline:

Biochemistry / Molecular biology

Sector:

University:

Program:

Globalink