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Second generation BMP2 for dental surgical applications
The intern will be producing a therapeutic protein, i.e. ‘biologic’ (BMP2) using mutated
bacterial plasmids as the bio-factory. The intern will create a sequence of DNA to be
transformed into E. coli cells (BL21). The cells will be grown up in the lab, and studied for
enhanced clinical efficacy. Proteins will be affinity purified and the resulting BMP2 variants
will be tested in lab bioactivity assays. With a more potent mutant BMP2, our partner will be
able to increase the number of successful implantation and reconstruction services they offer
as a smaller physical quantity of BMP2 will reduce illicit adverse immune events.
Faculty Supervisor:
Illimar Altosaar
Student:
Partner:
Dr Hassan Ghaderi Moghadam Professional Corporation
Discipline:
Life Sciences
Sector:
University:
University of Ottawa
Program:
Accelerate
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