Simulation of nanoparticle adsorption and transport in microfluidic lung-on-a-chip devices

Organs-on-chips are miniature devices mimicking aspects of human organ functions. Their main purpose is to serve as an alternative to animals as a testing ground for drugs, pollutants and toxins to see their effects on organs. The lung-on-a-chip device, which is the focus of this research, has been used to demonstrate how air-born nanosized particles can irritate the lung tissues and cause inflammation. It can also help us in designing sprays and aerosols for carrying drugs into the lungs. As the research on such devices is in its infancy, they are mostly made by trial and error, with little guidance from fundamental principles of mechanics, physics and biology. TO BE CONT’D

Faculty Supervisor:

James Feng


Seyed Mohammad Amin Arefi


Providence Health Care


Engineering - chemical / biological


Medical devices




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