SN-38 (or 5-FU) drug encapsulation in Iiposomes transported by magnetotactic bacteria for localizedcolorectal cancer treatment

Cancers are treated today with the appropriate combination of chemotherapy drugs, surgery

and radiation. Chemotherapy is almost invariably dosed intravenously, and enters the

systemic blood flow where it circulates around the whole body, coming into contact with

healthy cells as well as cancerous ones. This systemic dosing has two big problems: too little

drug gets to cancer cells, and too much drug comes into contact with healthy cells, causing

side effects. Frequently, these dose-limiting side-effects prevent us from delivering the

maximally effective anti-cancer drug dose.

Professor Sylvain Martel of Ecole Polytechnique de Montreal’s Nanorobotics laboratory has

pioneered an approach using special bacteria that can be directed by a magnE)tic field to

deliver chemotherapy directly to the site of tumors, reducing side-effects. With the support of

a team of co-investigators from McGill University (Drs. Te Vuong, Gerald Balisl, Maryam

Tabrizian, Nicole Beauchemin, Danuta Radzioch) and the Universite de Montreal (Dr. Louis

Gaboury),

Faculty Supervisor:

Sylvain Martel;Danuta Radzioch;Michel Lafleur;Maryam Tabrizian

Student:

Partner:

Quebec Consortium for Drug Discovery (Quebec, QC);Syzent Partners

Discipline:

Engineering

Sector:

Manufacturing

University:

École Polytechnique de Montréal; McGill University; Université de Montréal

Program:

Accelerate

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