Targeting the glycerophospholipidome to promote stroke and AD recovery

Alzheimer Disease complicated by covert stroke is the most common neurodegenerative disorder with 24.3 million patients worldwide. One new patient is diagnosed every seven minutes. The emotional toll is incalculable. Prognosis is bleak. Insidious cognitive decline eliminates a patient’s identity and renders victims dependent upon custodial care within 5-8 yrs. There is a pressing need for strategies that target the brain cell changes observed early in Alzheimer Disease and exacerbated by covert stroke. In this proposal, we argue that changes in the lipid composition of brain cells precedes memory loss and renders brain cells vulnerable to Alzheimer Disease and vascular dementia. It is known that families of lipids are altered over the course of Alzheimer Disease but they have, for the most part, been ignored given the technical challenges associated with identifying lipid subtypes……..to be continued on proposal application

Faculty Supervisor:

Steffany Bennett

Student:

Partner:

Sunnybrook Health Sciences Centre

Discipline:

Life Sciences

Sector:

University:

University of Ottawa

Program:

Accelerate