The Effects of Exercise on Grey Matter Volume in the Prefrontal Cortex and the Relation to Cognitive and Social Functioning in Schizophrenia

Decreased brain volume in frontal regions is a prominent feature of schizophrenia and has been linked to impairments in psychological and social functioning. These impairments persist over the lifespan, with approximately 64% of individuals experiencing severe social disability 15-years after illness onset. Finding ways to overcome barriers to better functioning is of utmost importance to patient quality of life. Recent evidence suggests that physical exercise can lead to increased brain volume, with implications for psychological and social functioning. The current study will investigate the efficacy of a 12-week aerobic exercise program for improving brain volume, and psychological and social functioning in chronic schizophrenia. Neuroimaging methods and standard neuropsychological tests will be used to evaluate changes from study entry to 12-week follow-up. This research aligns with the visions of BC Mental Health and Addiction Services in that it aims to advance best practices in mental health.

Faculty Supervisor:

Allen Thornton

Student:

Partner:

BC Mental Health and Addiction Services

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

Simon Fraser University

Program: