The study of action mechanism of indoles in Breast Cancer and Prostate Cancer

The indole subunit is a near-ubiquitous component of biologically active natural has become an important building block or intermediate in the synthesis of many pharmaceutical agents. Such as indole-3-carbinol, found in cruciferous vegetables has been shown to inhibit carcinogenesis. In this project I will focus on studying of action mechanism (cell apoptosis, angiogenesis inhibition and inhibiting microtubule formation) of indoles in breast cancer and prostate cancer. Establishment of models for the screening of indoles resources for resistance to breast and prostate cancer. A growth inhibition studies will be carry out by cell proliferation. Related hormonal status during growth inhibition test by Elisa kit.

Faculty Supervisor:

Sheng-Xiang Lin

Student:

Ruixuan Wang

Partner:

Discipline:

Biochemistry / Molecular biology

Sector:

University:

Université Laval

Program:

Globalink Research Award