Our hand function can be affected by different diseases and disorders, such as arthritis and neurological injuries. Having limited hand function will immensely affect our life and will make everyday simple tasks challenging. There are about 1 million Canadians who reported struggling with daily activities due to this limitation. One task that is challenging for […]

A current area of focus at SMT Americas is to develop injection-moulding methods for medical lab-on-chip (LOC) devices, particularly to transport and process blood and plasma while eliminating conduits clogging and reducing sample loss. This project will evaluate the effect of flow conditions on viscosity of samples, and the adequacy of conduit structures achieved with […]

Sepsis, severe pneumonia and respiratory viruses are key causes of Acute Respiratory Distress Syndrome (ARDS)—a detrimental lung condition that results in >3 million ICU admissions/year and can lead to organ failure and death. In Canada, ~18,000 patients with ARDS are admitted to hospital annually and those requiring critical care place an immense burden on hospital […]

This project aims to support ExCellThera’s current clinical trial (ECT-001) to improve blood stem cell transplantation outcomes for patients suffering from a host of blood malignancies. A critical aspect of developing clinical therapies using stem cells involves accurate and robust control of stem cell behavior in controlled laboratory conditions. Cell growth conditions (media) should mimic […]

Duchenne muscular dystrophy (DMD) is a genetic disorder resulting in progressive muscle degeneration. Satellos Bioscience Inc is developing small molecule drugs that target and modulate DMD muscle stem cells to repair the dystrophic muscle. Despite the advantages of DMD animal models, they are not always predictive of human DMD phenotypes, or their response to drug […]

For stem cell discoveries to translate into improved health solutions for Canadians, we must use engineering manufacturing practices to grow enough cells safely and efficiently. Pluripotent stem cells (PSCs) have the unique ability to transform into any cell in the body when subjected to specified environmental conditions. They are invaluable in studying disease and gene […]

Legionnaires is a disease caused by the bacteria Legionella pneumophilia present mostly in aquatic environments. The first outbreak of this disease was recognized in 1976 in Philadelphia and the most recent one in July 2019 in Atlanta. Diagnosis of the disease isn’t early and thus need to be prevented by regular treatment. Treatment of water […]

The purpose of this research is to develop improved diagnostic and treatment tools for prostate cancer in humans through the use of a canine (dog) model and a synchrotron-based x-ray source for imaging and therapy at the Canadian Light Source (CLS). Novel techniques in synchrotron x-ray imaging, specifically in-line phase contrast CT (PC-CT), will be […]

The most common solution to pectus carinatum is surgical. As braces begin to be developed that have been seen to reshape the chest successfully it becomes important to understand the effectiveness and optimal design thereof. Braceworks, has managed to create a low profile prototype brace which contains a protocol on how long to wear the […]

The project involves the development of a power amplifier for driving therapeutic ultrasound transducers such as those used in treating cancer and inducing blood coagulation. In particular, the design will make use of a unconventional amplifier topology, class E/F, and advanced GaN FET technology in order to maximize amplifier efficiency. High efficiency amplifiers are important […]

Digital Tomosynthesis (DTS) is an innovative imaging modality that provides 3D reconstructed images of inner organs, using conventional digital x-ray equipment. The image slices are reconstructed from a series of projection images acquired as the x-ray tube moves around the patient in a limited angle path. DTS improves the sensitivity of lesion detection, due to […]

Recent studies show that chronic stress levels have increased by 30% in the last 3 decades[1]. The objective of this project is to place humans at the center of a new mobile-based platform called the Life Optimization Engine (LION). The goal is to optimize human performance via self-modulation through physiological feedback programs. LION will use […]