Le projet vise à développer un nouveau vecteur de transport pour cibler et éliminer les cellules cancéreuses de manière précise et efficace. Notre approche consiste à concevoir et fabriquer un peptide catalyseur-médicament doté de propriétés radiothérapeutiques ou chimiothérapeutiques. Les cellules cancéreuses ont développé différents mécanismes de résistance afin diminuer l’accumulation intracellulaire des médicaments dont la […]

The study’s primary goal is to understand the impact of pipeline construction on the behaviour of migratory birds. It will focus on assessing how the proximity to different construction activities, different habitats, environmental conditions and nature of construction work affect nest attendance, alertness and flushing behaviour of the migrants. Anthropogenic activities can adversely affect the […]

This project is going to evaluate an experimental media for improved detection of pathogenic E. coli, the same type of E. coli that led to the recent outbreak in Calgary daycares that affected approximately 320 children. We will be rigorously testing the new media by evaluating the abundant E. coli present in the feces of […]

The current treatment of cervical dystonia (Torticollis) uses Botox® (onabotulinumtoxinA) is an approved treatment by Health Canada and FDA. Botox® injections help to correct abnormal movements of the neck as well as any severe discomfort and pain related to the movement disorder. At present clinical limitations still exist for Movement Disorder Neurologists as it is […]

Current treatment options for tremor, the most common movement disorder, are quite poor. Discontinuation of compliance to oral medications is due to significant side effects and no noticeable benefit in tremor severity. Botulinim toxin type A is a recognized tremor therapy however, adverse events and the inability of Movement Disorder Neurologists to visually locate these […]

The proposed project aims to develop neural decoder models that can interpret brain signals in real-time to control stimulation devices, specifically focusing on Epidural Electrical Stimulation (EES) for upper limb rehabilitation. By implementing a continuous learning paradigm in decoders, the project seeks to enable the models to compensate for the effects of stimulation and adapt […]

Parkinson’s disease (PD) is neurodegenerative disorders including motor symptoms linked to the loss of dopaminergic neurons in the Substantia Nigra pars compacta. The etiology is still unknow, but data suggest an important role of mitochondrial dysfunction in the onset of this disease. The vulnerability of dopamine neurons seems to be related to their particularly high […]

Ovarian cancer is the most lethal gynecologic malignancy and treatment strategies have remained unchanged for decades. A hallmark of tumour progression is the ability to rapidly develop new blood supply; however, aggressive growth signals result in dysfunctional blood vessels that reduce tumour perfusion and promote hypoxia. This tumour microenvironment promotes chemoresistance and suppresses natural and […]

The proposed project will support an international collaboration between researchers at the University of Toronto and the University of Melbourne / Orygen. As an integrated youth mental health service centre, built by top researchers leading mental health service reform internationally, Orygen provides an optimal setting to conduct research into complex processes of resilience and functional […]

Le projet de recherche cherche a valoriser les sous-produits de l’agriculture urbaine pour en révéler le plein potentiel fertilisant . Pour se faire, la mission des stagiaires consistera à développer des protocoles novateurs puis caractériser l’impact de ces fertilisant sur les agroecosystemes. Ils concevront des procédures de d’utilisation de ces matières telles que: 1) actuellement […]

This project explores the potential of low-tech biochar production using an invasive species to mitigate climate change and generate carbon credits. Focused on Kenya, the research assesses the viability of this practice, considering factors like feedstock availability, production data, and environmental impacts. The team aims to provide communities, policymakers, and investors with valuable insights through […]

Increasing concentrations of colored dissolved organic matter (CDOM) due to land-use permafrost thawing and landscape vegetation are darkening Northern Hemisphere freshwaters. In addition, mining activities increase water turbidity. In Chile, the same phenomena are observed, and melting glaciers are also responsible for increased turbidity. CDOM and turbidity are part of the optical habitat of fish, […]