Tissue-resident fibroblasts and their attendant activities are central drivers of a diverse range of diseases. The overarching theme of this proposal is to develop novel fibroblast reporter lines that will enable us to identify tractable therapeutic targets to modify fibroblast activity. To identify such targets, we are proposing to carry out high throughput screens (i.e., […]

Cancer is a leading cause of death worldwide. One of the main ways to remove cancer cell is targeting them using beta and alpha particle radiation. These kinds of radiations can be reached to the cancer sites by attaching them to special drugs that have specific binding sites on their cells. However, there is no […]

The development of human papillomavirus (HPV) vaccine led to a reduction in the incidence of cervical cancer in women. But in low- and middle-income countries, the adoption of HPV vaccine is low. Hence why women are more likely to develop cervical cancer in those areas. There is a lack of understanding of the patient’s point […]

There is no cure for psoriatic arthritis (PsA) and current treatments aim at reducing inflammation, slowing the progression of the disease, and avoiding severe damage to the skin and joints. Immune cells contribute to inflammatory cascades in the joints and the skin that produce inflammatory cytokines and lead to severe tissue damage. Current therapies are […]

Forage blends also known as cocktails or polycrops are gaining popularity among beef producers and are being incorporated into grazing systems. Winter swathgrazing is a strategy that allows beef producers to extend cattle grazing activities into the fall and winter months, which provide some economic and environmental benefits that enhance farm sustainability. Adequate feed supplies […]

Brain injury, a leading cause of disability worldwide, affects a person’s mind and body. After injury, the brain needs more oxygen to begin recovery, which can result in a problematic process called “oxidative stress”. This research tests if training your brain with a video game, NeuroTracker, reduces oxidative stress, and improves brain injury-related outcomes. The […]

L’industrie pharmaceutique est soumise à de nombreuses normes et exigences en matière de qualité, ce qui en fait l’un des secteurs les plus réglementés. La gestion de ces exigences implique une documentation importante qui nécessite une gestion rigoureuse. Cependant, lorsque cette gestion documentaire n’est pas dématérialisée, elle peut être lourde. C’est dans ce contexte que […]

BIOVECTRA is a North American CDMO focusing on optimizing, adapting, and perfecting innovative technologies and drug substance development to deliver effective and novel solutions for pharmaceutical manufacturing. Challenges and opportunities include: • Solving complex therapeutic challenges in collaboration with partners through contract development and manufacturing • Offering products and services of exceptional caliber, on time […]

Industrial, shipping, and agricultural activity over the last 100+ years have contributed a significant number of contaminants to the St. Lawrence River, causing health and cultural consequences for the local population, especially the local Indigenous community. Contaminants also affect the local ecosystem, and these impacts need to be better understood in the St. Lawrence River. […]

Over 5000 rare genetic diseases collectively affect 1 in 12 Canadians. For these disorders about 10% of patients share a common mutation type that introduces a premature termination codon (PTC) in the gene and results in truncated and non-functional protein. The previously found PTC suppressors have limited effect or unacceptable side effects. The goal of […]

The Canadian cannabis industry currently relies on indoor growth facilities where the environment can be carefully controlled to grow ‘bud’, which are actually the flowers of cannabis plants. Indoor plant production is energy-intensive, so switching to high-efficiency LED lights can save energy, reducing costs to the producer and the environment. In this study, the best […]

There is an increased threat of disease caused by viruses transmitted by mosquitoes because of changes in climate and land use. In general, two types of viruses are found in mosquitoes: viruses transmitted to humans and animals that can cause disease, like West Nile virus, and viruses that only infect the mosquito, called insect-specific viruses. […]