Le cancer du sein triple négatif (CSTN) est un sous-type très hétérogène de cancer du sein qui présente un mauvais pronostique pour les patientes. En plus de présenter des taux élevés de chimiorésistance, l’importante hétérogénéité intra-tumorale du CSTN complique grandement le traitement des patientes. La progression tumorale est caractérisée par la régulation réciproque des reprogrammations […]

People living with IBD, grave and lifelong disease, have gut damage and pain. Fibers can improve gut health in healthy people, but they are not digested in the gut. Instead, they are broken down by gut microorganisms (bacteria and fungi) in a process called fermentation. But the types and amounts of gut microbes in IBD […]

The financial implications of time lost from work due to disability can be severe. Disability insurance coverage plans protect people from possible loss of income. We have found factors that predict the duration of disability benefit claims. However, it remains to be seen whether these associations are consistent. Improved understanding of modifiable factors associated with […]

Disorders of ovarian function are major causes of infertility, subfertility and cancer in mammals. For this reason, our research interest is the study of ovarian physiology and dysfunction; particularly the regulation of ovarian follicle development and ovulation in cattle. Recently, we generated considerable insight into the regulation of a completely novel signaling pathway during ovarian […]

Russian invasion of Ukraine began in February 2014 after Russia’s illegal annexation of Crimea. A larger invasion took place on February 24, 2022. Both conflicts have caused the displacement of 8 million Ukrainians to date. This is the largest humanitarian crisis in history since World War II. A significant percentage of these Ukrainian refugees have […]

Being physically active is associated with many health benefits. To help guide people on how much activity they need for optimal health, the Canadian Society for Exercise Physiology developed new Canadian Physical Activity Guidelines for all age groups. Specifically, this work will look at assessment, awareness, and uptake of the new guidelines as it relates […]

Alkynamides are very promising inhibitors of tyrosine kinases, important enzymes that can cause cancer when being too active in cells due to different mutations. While being important moieties, until recently there was no convenient method to synthesize them using carbamoyl fluorides — most protocols use either dangerous or expensive and ecologically unfriendly reagents, which always […]

Safe and healthy weight loss is becoming increasingly important as the obesity burden in Canada continues to grow, with 63.1% of adult Canadians classified as overweight or obese in 2018 according to Statistics Canada. Ketogenic diets are diets that are low in sugar and are very popular for weight loss. However, these diets may be […]

T cells are specialized immune cells that protect us against infection and cancer. These cells express a molecule (known as the T cell receptor, or TCR) which recognizes a small portion of foreign or abnormal proteins presented on the surface of infected or cancer cells. The interaction between the TCR and this small protein fragment […]

L’analyse des données de vie réelle (Real-World Data) pour générer des preuves du monde réel (Real-World Evidence) est une pratique en croissance dans l’industrie pharmaceutique. La loi 21st Century Cures Act, signée en décembre 2016 par le Congrès américain sous l’administration Obama, a amplifié l’engouement pour l’utilisation des données de vie réelle (RWD) dans l’industrie […]

Ecmius Biomedical is a Canadian company that is invested in the research, development, and future production of extracorporeal life support (ECLS) technology, including extracorporeal membrane oxygenation (ECMO). ECMO is an invaluable tool that can support the treatment of adults and children with severe cardiac and/or pulmonary dysfunction, maintaining patient condition until longer-term treatments become available. […]

Acute lymphoblastic leukemia (ALL) is the most common hematological cancer in children. 10 to 15% of pediatric cases are of T cell origin (T-ALL). Current intensive multidrug therapy can achieve high cure rates, yet associated with serious long-term adverse effects, including secondary cancers. Moreover, 15% of children will relapse, facing a poor prognosis. We previously […]