Radiochemistry for the Pharmacokinetic Evaluation of Novel Bone-Targeting Peptide Hormone Derivatives Year Two

This proposed research project is about development of new bone-targeting drug called PTHPEG- BP, this new compound will overcome shortages of current clinical peptide hormone PTH, and show better treatment efficacy and lower price then the latter; several new technologies will be used on research of this PTH, such as micro Positron Emission Tomography (PET/CT), […]

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dCBT for Insomnia app

Tranq Sleep Care is focused on providing high-quality sleep care and creating new innovative solutions to diagnosing and treating sleep disorders. Tranq is currently developing an online web app that aims to help people suffering from insomnia. The challenge in delivering the treatment through an app is that it must be made such that patients […]

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Do urban environments favour certain plant reproductive strategies?

Urbanization can have a strong impact on biodiversity. In particular, the changes in temperature, habitat fragmentation and pollution are expected to affect the species that are present in cities, both directly and indirectly via their effects on other species. In this proposal, we aim to test if certain plant reproductive strategies are favoured by urbanization. […]

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Impact of environmental factors on spontaneous reporting trends and safety signal detection in the EudraVigilance database

Changes brought to the ecosystem and geopolitical environment can have an effect on several fields including the healthcare system. Recently, we observed the impact that COVID-19 pandemic has had on the healthcare workers’ practices and people’s behaviour regarding their health status. Changes in spontaneous reporting trends were also observed. Lately, Europe has also witnessed the […]

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Targeting Radiation-Induced CXCL12/CXCR4 Signaling and the Immune Microenvironment to Improve the Radio-Curability of Human Cancer

Medical images were collected from cervical tumors from mice undergoing cancer treatment using radiation to kill cancer cells and shrink tumors. The purpose is to discover new biological molecules and observe the immune system reacts during radiation treatment. These images will be analyzed by MATLAB, which is a computer platform. MATLAB will perform a couple […]

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Screening DNA Methylation Signatures in Early Bovine In Vitro Embryos for Developmental Fitness

The success of assisted reproductive techniques (ART) in overcoming infertility or improving livestock genetic traits is undeniable. However, the use of ART in livestock has also been associated with an increased likelihood of certain anomalies (e.g., large offspring syndrome, musculoskeletal anomalies) and neonatal mortality because of suboptimal culture conditions. Our partner, L’Alliance Boviteq (Semex) has […]

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Non-Viral delivery of insulin and IL-10 to the intestine for immunotherapy for type 1 diabetes Year Two

There is increasing evidence suggesting a link exists between the gut immune system and several autoimmune diseases, including diabetes. The industrial partner of this project, enGene, has developed an effective non-viral based technology for the delivery of genes to the intestine. enGene has demonstrated the feasibility of delivering IL-10, which is an anti-inflammatory cytokine, to […]

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INVESTIGATION INTO ANTI-DIABETIC, ANTI-MICROBIAL AND HYPOLIPIDEMIC PROPERTIES OF SORBUS DECORA USED IN THE MANAGEMENT OF DIABETES – EFFECTS ON PI3-K/AKT SIGNALLING PATHWAY

Diabetes mellitus (DM) is a metabolic disease, which is characterized by insufficient or inefficient insulin secretory response and elevated blood glucose level (Prabhakar and Doble, 2008). In 2021, 536.6 million people worldwide suffered from diabetes and this number is projected to grow to 783.2 million by 2045 (Sun et al., 2022). Sorbus decora (SD), commonly […]

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Investigating the biophysics and structural basis for state dependent drug blockade of persistent/late sodium current (INa(P)) in the heart using photoactivatable crosslinking unnatural amino acidsYR2

Electrical activity in the heart is controlled by the concerted activity of many proteins called ion-channels that regulate the transfer of different ions across cell membranes. Recently, researchers in biomedical science have identified that a particular component of sodium carrying ion-channel activity (called the persistent or late sodium current also known as INa(P)) played a […]

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