The detection of a biological agent has become paramount to anticipate a possible health threat (epidemic or pandemic), an environmental threat or to combat other contextual threats (bioterrorism, chemical and biological weapons). A cost effective, portable, reliable and safe solution is required to allow detection in location where biological equipment is not available (such as […]

Opioids have received much attention in the media, public and government because of the risks associated with them, including fatalities. Concurrent use of BZRAs (benzodiazepines used for treating anxiety and insomnia) and opioids is of particular concern because this is a recognized risk factor for fatal opioid overdoses. Despite this warning, concurrent use is still […]

Host cell proteins are inevitable contaminants of biopharmaceuticals. Here, we performed detailed analyses of the host cell proteome of moss (Physcomitrella patens) bioreactor supernatants using mass spectrometry and subsequent bioinformatics analysis. Distinguishing between the apparent secretome and intracellular contaminants, a complex extracellular proteolytic network including subtilisin-like proteases, metallo-proteases, and aspartic proteases was identified. Knockout of […]

Bisphenol A (BPA), and its analog bisphenol S (BPS) are synthetic compounds commonly found in plastic products, and chronic exposure has been associated with adverse health outcomes such as the development of insulin resistance and type 2 diabetes (T2D). Low levels of these pollutants can transfer from polymers to food or water and can accumulate […]

L’objectif principal de ce projet est d’améliorer les connaissances sur le devenir du phosphore (P) et les facteurs interférents et d’utiliser ses connaissances pour développer un modèle mathématique représentant le devenir du P et du calcium (Ca) alimentaires chez la truie afin d’optimiser leur utilisation, de mieux définir les priorités de recherche et d’établir des […]

Facioscapulohumeral muscular dystrophy (FSHD) is a debilitating disease resulting from the loss of skeletal muscles mainly in the face, shoulder blades and upper arms. FSHD results from expression of the protein DUX4 which causes skeletal muscle cell death and therefore loss of muscles. This project aims to immortalize isolated skeletal muscle cells from patients with […]

Blueberry is a soft fruit species for which consumption has increased drastically in the last two decades. The rapid increase in consumption is mainly driven by the health benefits and pleasant flavour of the fruit. However, consumers assess fruit quality in terms of flavour, texture and aroma and use these features as the main criteria […]

The TRAPP complex is a large protein complex involved in a number of different cellular processes including membrane traffic. Individuals with mutations in the genes encoding the proteins of this complex have been increasingly identified using whole exome and whole genome sequencing methods. To date, only a single individual with a candidate (and not yet […]

Parkinson’s disease (PD) is the second most common neurodegenerative disease. PD is caused by genetic predispositions leading to neuronal cell death. Dysfunction of damaged mitochondrial turnover by mitophagy (mitochondrial autophagy) and the ubiquitin-proteasome system has been found in most cases of genetic PD. The ubiquitin-proteasome system mediates protein degradation trough ubiquitination – a post-translational modification […]

Autism spectrum disorder (ASD) is characterized by social and communication impairments and by restricted and stereotyped behaviors. Sensory processing alterations seem to have an important toll in ASD individuals. In the present study, ASD and typically developing (TD) children between 8 and 12 years old will participate in a task involving visual and auditive integration […]

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by social communication deficits, restricted interests and repetitive behaviours. Accumulating evidence suggests neuroimaging to have a great potential in clarifying the neurological bases of ASD. In this project we will use magnetoencephalography (MEG) to investigate the neuromagnetic mechanisms of information processing in typical and […]

Using genome-wide data in collaboration with the Peruvian Genome Diversity Project, our goals are: (i)Populations from the Peruvian Central Andes are highly homogeneous. We use Approximate Bayesian Computation and patterns of identity-by-descent to infer when the intensification of the gene pool homogenization on this geographic region started, in the historical context of the Andean prehistory. […]