Significant advances in technologies related to antibody discovery and development have allowed therapeutic antibodies to become the fastest growing class of biopharmaceuticals over the last 20 years. Northern Biologics is a biotechnology company that seeks to develop therapeutic antibodies for the treatment of cancer and fibrosis. Together with Dr. Jean-Philippe Julien at SickKids (University of […]

The consumption of n-3 polyunsaturated fatty acids (PUFA)-rich eggs is associated with human health benefits because dietary PUFA reduces the risks of cardiovascular diseases, inflammation and cancer. Flaxseed is an excellent source of PUFA, especially linolenic acid. However, flaxseed contains anti-nutritional factors (i.e., cyanogenic glycosides, mucilage and phytic acid), which causes liver hemorrhage in laying […]

Coronary artery disease is caused by a build-up of plaque in the heart vessel. If the plaque causes a large amount of blockage, this can restrict the flow of blood to the heart and cause a heart attack. However, certain types of plaque are fragile (vulnerable) and can transform from a non-obstructive to obstructive blockage […]

Bones undergo a renewal process by replenishing calcium mineral through a cellular process known as remodeling. Usually, it happens in a balanced manner, but in many bone diseases, the remodeling process is increased with regional bone metabolism. Bisphosphonate (BP) drugs selectivity and strongly bind to bone mineral and become incorporated at active sites of bone […]

Bones undergo a renewal process by replenishing calcium mineral through a cellular process known as remodeling. Usually, it happens in a balanced manner, but in many bone diseases, the remodeling process is increased with regional bone metabolism. Bisphosphonate (BP) drugs selectivity and strongly bind to bone mineral and become incorporated at active sites of bone […]

Insect pollinator health is a crucial component of managed and natural landscapes due to their important impact on crop pollination and ecosystem equilibrium. Some pollinator populations have experience notable declines, due to changes in habitat, presence of pests and pathogens, pesticides and toxins present in the environment as well as nutritional requirements. A proper identification […]

Allergic asthma is a condition of the airways characterized by airway constriction and hyperresponsiveness upon allergen exposure. About half of the allergic asthmatic individuals experience only an acute airway constriction (early response) within several minutes upon exposure to allergen while the other half of individuals experience not only an acute airway constriction but also a […]

The coastal marine regions of Canada are an excellent source of renewable energy. Tides and currents are predictable in space and time so ideal for tidal energy. Coastal areas with strong currents are also popular with marine mammals often providing good feeding opportunities. However little is known about how marine mammals will be affected by […]

The role of infectious disease in declining productivity of wild salmon in BC is poorly understood. We will combine novel genomic technologies with traditional fish health methodologies and more broadly identify the microbe exposure of BC salmon. By doing so, we can examine their evolutionary relationships and their epidemiological distribution patterns over time and space […]

Cognitive impairments are the most common long-term challenges after traumatic brain injury (TBI). There is very little research on interventions to improve cognitive function after brain injury. The goal of this project is to evaluate whether and how an intensive cognitive intervention program (Arrowsmith program) may stimulate positive changes in the brain. We have already […]

Organ transplants save patients with severe end stage organ failure but the need for subsequent lifelong immunosuppression can lead to a number of undesired consequences including the reactivation of viruses of donor or recipient origin. Human cytomegalovirus (HCMV) infection is the most common opportunistic infection in transplant patients and can lead to significant morbidity and […]

Today 25% of patients listed for liver transplantation die waiting for a liver to become available. The donor organ pool could be expanded by rescuing the 50% of livers donated after cardiac death (DCD) that are discarded due to the injury caused by prolonged periods of warm ischemia during organ retrieval. Mesenchymal Stromal Cells (MSC) […]