Our brain is controlled by two systems: excitatory systems and inhibitory systems. The balance between these two systems is essential for normal brain functions. Our lab has found that glutamate, a key neurotransmitter in excitatory systems, can act at GABAAR, a key receptor in inhibitory system, and improve GABAAR’s function. This is a novel form […]

Le cancer du sein touche une femme sur 9 au cours de sa vie en Amérique du Nord. Il s’agit d’une maladie hétérogène et il est important d’adapter les traitements au profil biologique de la tumeur. Le but de ce projet est de développer une méthode d’analyse d’échantillons de tumeurs mammaires basée sur 300 marqueurs […]

Ce projet de recherche est mené en Estrie sur des plantations de peupliers hybrides, une espèce d’arbre à croissance rapide fort intéressante pour l’industrie forestière, particulièrement depuis que le Québec s’oriente vers une intensification de la sylviculture. Parallèlement, une nouvelle loi devrait prochainement interdire l’enfouissement des matières résiduelles organiques; il devient donc primordial de trouver […]

Depression is a disabling condition affecting millions of people. Some of the symptoms of depression make it impossible for people to function in their daily lives. People experience significant levels of memory, thinking, planning and other cognitive symptoms that impair their abilities to go to work, school and take care of themselves and family. What […]

The number of children being driven to school has substantially increased over the past few decades—fewer children are walking or bicycling to school. There is good evidence to suggest that programs promoting walking or cycling to school may increase physical activity in children’s lives. With limited funds available, it is important to document the effectiveness […]

L’utilisation à large échelle de produits phytosanitaires de façon préventive, tels que les fongicides foliaires, peut causer des impacts sur l’environnement et sur la santé humaine. Les conditions d’utilisation, les bénéfices anticipés mais aussi les impacts indirects liés à l’utilisation de ces produits doivent être examinés au Québec. Par exemple, les fongicides foliaires utilisés dans […]

Enzymes are becoming important industrial catalysts, especially for “green” manufacturing. As a consequence, much interest currently exists in identifying ways to optimize the catalytic properties of enzymes to make the manufacturing process more efficient. One way to do this is to create many variants of the original enzyme, each differing slightly in structure, and then […]

Chez les plantes à fleurs, la reproduction sexuée fait intervenir une cellule mobile, le tube pollinique, sorte de « spermatozoïde végétal », qui doit se déplacer jusqu’à un ovule pour le féconder. Pour l’assister dans cette tâche, l’ovule sécrète de petites molécules attractives que le tube pollinique perçoit grâce à des récepteurs. Bien que ce […]

The high cost and low quality of meat sold in the north make subsistence fishing and hunting of vital importance to the Inuit. Accordingly, the reported decline in the condition of Arctic charr from the Deception River was of concern to all stakeholders, e.g., Government, local industry, but particularly to the Inuit and their representatives. […]

Southern Ontario is one of the most critical regions in Canada in terms of wildlife-human conflict. It has one of the highest proportions of species at-risk but also dense human population and agricultural productivity. This project proposes to research whether habitat for at-risk pollinators can be adequately incorporated onto private farmland using methods from natural […]

Aurin Biotech has demonstrated that aurintricarboxylic acid (ATA) and related hydroxyarylmethane derivatives are potent inhibitors of the terminal complement cascade. The complement cascade is a potent initiator and enhancer of the inflammatory response which leads to pathophysiological consequences including cell death and tissue remodeling in a range of chronic diseases. This project uses two distinct […]

Glioblastoma (GBM) is the most common primary adult brain tumor, characterized by extensive cellular and genetic heterogeneity. Even with surgery, standard chemotherapy, and radiation, tumor recurrence and patient relapse are inevitable with a median survival rate of