Development, implementation and validation of new anti-E6 therapeutics for the treatment of HPV-associated cancer

Human papillomaviruses (HPVs) are responsible for almost all cervical cancers. Current treatment available relies on chemo- or radiation-therapy or surgery. These methods have several side-effects with high morbidity and survival of just ~ 70%. Our lab, therefore, develops a more patient-centered approach based on targeting the viral E6 protein, the main culprit of carcinogenesis in […]

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Development, implementation and validation of new anti-E6 therapeutics for the treatment of HPV-associated cancer – Year two

Human papillomaviruses (HPVs) are responsible for almost all cervical cancers. Current treatment available relies on chemo- or radiation-therapy or surgery. These methods have several side-effects with high morbidity and survival of just ~ 70%. Our lab, therefore, develops a more patient-centered approach based on targeting the viral E6 protein, the main culprit of carcinogenesis in […]

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Sum rules and coset functions in multiphoton interferometry

We study an interferometer where light is injected via a fixed number of input ports. Inside the interferometer, light coming from different ports interacts, generating non-trivial outputs. Simulation of the output is exponentially hard for a classical computer: validating the output cannot be done under realistic conditions. We seek to formulate a validation procedure, i.e. […]

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Scaling simulations in population health via machine learning

Computer simulations provide a safe alternative to taking a trial-and-error approach in the real-world. If a simulating intervention is found to be inefficient or even harmful, then it can be canceled without causing harm to real individuals. Consequently, simulations are increasingly sought after for complex social problems such as homelessness and the spread of the […]

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Rheological and microstructural properties of micellar solutions

Surfactant solutions are of immense scientific and technological interest. They can self-assemble into wide variety of interesting and highly dynamic nanostructures including spherical, cylindrical, vesicle, worm-like or lamellar type. Micellar solutions typically contain surfactants and salts that are dissolved in water. Beyond a critical micelle concentration, the addition of salt or surfactant transforms spherical micelles […]

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A study on the application and mechanism of action of the lichen Umbilicaria muhlenbergii fractions on osteosarcoma and chondrosarcoma cells as a promising anticancer source

The purpose of this study is to determine the effect of the lichen Umbilicaria muhlenbergii fraction(s) on osteosarcoma and chondrosarcoma cells. MTT assay will demonstrate the activity of these fraction(s) against cancer cells. Appoptosis and inhibition growth analyses will be examined. The following objectives in the allocated time of five months (June 1-October 30, 2019) […]

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