Patients with advanced Parkinson’s disease (PD) may develop motor complications caused by Levodopa, the current drug used for treatment. Deep brain stimulation (DBS) is an alternative surgical treatment where electrodes are implanted in a specific brain region to deliver current to surrounding brain tissue which helps to alleviate motor symptoms of PD. Presently, there is […]

Although life expectancy is increasingly associated with the treatment of heart disease and cancer, there has been virtually no improvement in life expectancy for patients with dementia. Dementia has a devastating impact to the patient, family members and society because patients become dependent on family caregivers, who are then less productive in other aspects of […]

There is a critical need for new therapies for Parkinson’s Disease (PD), a devastating neurodegenerative disease. Current therapies for PD treat disease symptoms, but do not provide a cure. The ability to generate patient brain-derived cells may rapidly advance development of personalized therapies for PD and other incurable neurological disorders. This study will use brain […]

During a medical imaging exam, patient motion such as breathing, cardiac motion, and random adjustments of the head or body can affect the accuracy of the acquired images. Positron emission tomography (PET) is a powerful medical imaging technology that can detect minute amounts of an injected probe targeting specific tissue processes and diseases. Magnetic resonance […]

Patients with end-stage renal failure (ESRF) require hemodialysis (HD) to clear their blood from metabolic waste products. While generally considered mildly invasive, research shows that HD can induce severe side effects, often affecting microvascular blood flow in tissue. We successfully developed a small animal model that allows us to successfully dialyze laboratory rats (approx. 250 […]

During a medical imaging exam, patient motion such as breathing, cardiac motion, and random adjustments of the head or body can affect the accuracy of the acquired images. Positron emission tomography (PET) is a powerful medical imaging technology that can detect minute amounts of an injected probe targeting specific tissue processes and diseases. Magnetic resonance […]

Gallium-68 (68Ga) is a radioactive isotope that undergoes a decay process that emits gamma rays suitable for an imaging technique called Positron Emission Tomography (PET). The 68Ga is attached to molecule which targets the isotope to specific types of cancer such as prostate and neuroendocrine. With a relatively short half-life, it means that half of […]