Modulating chromatin remodeling to reverse immune evasion in ovarian cancer

Immunotherapy has achieved remarkable responses in cancers that were once fatal. However, Ovarian Cancer (OC) clinical trials have shown disappointing responses with immune checkpoint blockade (ICB). Our research team is studying how to target the factors influencing interactions between OC and immune cells to improve the treatment of OC. One particular target is the SWI/SNF […]

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Building Capacity for Patient-Oriented Research in Nephrology: A Digital Approach to Overcoming Barriers

Chronic Kidney Disease (CKD) affects about 1 in 10 people in British Columbia, placing a significant strain on the healthcare system. Patient-oriented research (POR) helps improve health outcomes by involving people with lived experience as active partners in research. However, many researchers face challenges to training, making it difficult to adopt POR. This project, in […]

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Development of reprogrammable metamaterial midsole for footwear

Athletic footwear is designed to enhance performance, comfort, and injury prevention. Current midsoles provide a level of performance that cannot be changed after fabrication, forcing a user to wear different pairs of shoes, each specialized for a given sports activity. For example, running shoes require high energy return for efficiency, whereas basketball shoes prioritize energy […]

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Building efficiencies and expanding the reach of training curriculum for cell & gene therapies biomanufacturing

The Canadian Advanced Therapies Training Institute (CATTI), is filling the shortage of qualified, job-ready talent by developing and scaling e-learning and on-site GMP training programs for cell and gene therapies (CGT) production to rapidly upskill the biomanufacturing workforce in Canada and internationally. Using industry-focused best practices for competency based demonstration of acquired skills in operating […]

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Cold-season subtropical air mass intrusions into the Saint-Lawrence River Valley: dynamic-thermodynamic impacts on extreme precipitation and regional climate change

The heavily populated region of Québec’s Saint Lawrence River Valley (SLRV) experiences among the largest number of hours of freezing rain on the North American continent. Some of the region’s most impactful freezing rain events, including the Great Ice Storm of 1998 and the recent April 2023 ice storm, were characterized by very warm, moist […]

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Identifying resistant short-season soybean breeding material and QTL involved in sudden death syndrome (Fusarium virguliforme) resistance in two short-season soybean breeding populations

Soybean sudden death syndrome (SDS), caused by Fusarium virguliforme, causes yield losses amounting to $ 500 M and $ 32 M (CAD) in the USA and Ontario annually, with yield losses reaching 100% in affected fields in epidemic years. Resistant cultivars are one of the most effective ways of minimizing yield losses due to SDS. […]

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CAE Simulator Training Workflow & Analytics Solution

The Project is to define the requirements to be used in the evaluation of feasibility and estimate of next generation of Simulator Training Workflow & Analytics Solution tool. It will leverage an existing Standard Operating Procedure workflow tool, to modernize its features to ensure that CAE (and potentially end client) users can find answers to […]

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Preventing ice accretion on electrical utility infrastructure by surface engineering

Every winter Quebecers, Canadians and basically anyone living in northern climates suffer from icing related failures (power blackouts, fallen trees, blocked roads, etc.). In the best case, meteorological forecasts and HQ’s ice-removal measures are timely, costly, and the society does not experience the severe effect caused by harsh winter weather. Currently applied active ice protection […]

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AI for Template based Multi-physics eMachine Design

Electrical machines are fundamental to the operation of modern society – from household devices and transportation to industrial operations and power generation. However, designing these devices is a slow and complex process. Many components of the process date back over a century and constrain the devices that can be produced. With technologies such as additive […]

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Advanced stability and dynamic analyses of shallow arch bridges and railway bridges

Bridge engineers deal with various bridge systems to satisfy ever-increased bridge design requirements in safety, functionality, cost, aesthetics, etc. The proposed project aims to investigate in depth the stability and dynamic behaviours of two distinguished bridge systems. One is the shallow steel arch bridge susceptible to non-linear snap-through buckling, and the other is the railway […]

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