The MAID Study: Microbiome and Antibiotic-Induced Dysbiosis in Children

Antibiotics are the most widely prescribed drugs in children and its frequent use presents a real danger to its ongoing effectiveness. Probiotics are bacteria that, when administered in adequate amounts, may replenish “good” bacteria depleted by antibiotics to maintain the normal bacterial composition in the gut. The aim of this study is to determine whether […]

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Budget impact analysis for single stage breast implantation reconstruction in women with a mastectomy

Women with breast cancer often undergo mastectomy, or removal of the breast. Afterwards, they may elect to reconstruct their breast using one of several methods. One of these methods is by implantation with a permanently adjustable prosthesis. This procedure may show a smaller budgetary impact compared to multi-staged implantation. This project will estimate the budgetary […]

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Development of Novel Cellulose Bioprinting Materials Using Thilo-ene Click Chemistry for Application in 3D Printing/Structuring

Recently, new development of 3D printing and patterning technologies offering advantages such as low cost, rapid prototyping, and high resolution have captured the attention of consumers, producers, and scientists alike. Although 3D printing and structuring methods have evolved over time, the materials used have not. Cellulose is a natural material that exists all around us […]

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Autonomic control of thermoregulation during exercise in spinal cord injury

In able-bodied individuals, increases in core temperature during exercise are controlled by the nervous system as a sweating response. However, individuals with spinal cord injuries (SCI) may have altered sweating responses due to autonomic dysfunction, leading to increased risk of heat stress during exercise. Currently, standard tests do not fully describe how temperature regulation is […]

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Management of posttraumatic stress disorder: a multiple treatment comparison meta-analysis of randomized controlled trials

Traumatic events such as work related accidents, injuries or assault may result in the development of post-traumatic stress disorder (PTSD). This condition is associated with sleep disruption, nightmares, anxiety, and avoidance of the environment where the traumatic event occurred. Significant proportions of patients diagnosed with PTSD are disabled from working; however, little is known regarding […]

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Improving implementation of the intensive lifestyle intervention and accuracy of lifestyle data collection in the REMIT-Dapa trial.

Type 2 diabetes (T2D) results in high blood sugars and can cause serious complications. Recent studies suggest that treatment with diabetes medications along with lifestyle changes can result in patients not needing diabetes medications for months or even years, a concept known as diabetes remission. The Remission Evaluation of Metabolic Interventions in Type 2 Diabetes […]

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Storytelling Medicine

Fear is considered a natural reaction when a child visits the hospital. Much research has been done to understand what causes it and how to treat it. Current methods to treat child hospital fear works on decreasing anxiety at specific points in the procedure. This project will investigate creating a series of tools and procedures […]

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Formulation and clinical translation of a novel DOX-DelivraTM transdermal treatment for diabetic foot ulcers

This research project aims to develop a novel treatment for diabetic foot ulcers. Individuals with diabetes (3.4 million Canadians) exhibit impaired healing of acute wounds, and 15% (~510,000) are estimated to develop chronic non-healing diabetic foot ulcers (DFUs). DFUs precede 84% of all diabetes related lower leg amputations. Typical DFU treatment is excising devitalised tissue […]

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Computer Vision and Deep Learning for Moderating Visual Content

Two Hat Security is a company that develops next generation moderation tools for social networking apps. Since visual content (e.g. images, videos) is one of the most important types of data shared by social networking apps, an important problem for the company is to identify images/videos that are offensive or inappropriate. For example, certain images/videos […]

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The role of integrins in stretch-induced activation of TGF-?1 and pulmonary fibrosis

Fibroproliferative disorders are the leading cause of morbidity and mortality worldwide. A large group of interstitial lung diseases (ILD) can cause progressive scarring of lung tissues, affecting the ability to breathe. Idiopathic Pulmonary Fibrosis (IPF) is one of the major forms of ILD and is characterized by a progressive decline in lung function. Although the […]

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Improvement of Technology for the Development and Production of Specialty Chemical Products

High-end chemical products, such as specialty polymers and pharmaceuticals, are important to provide a high quality of life. The effectiveness of these products is dependent on intensive development and consistent production. The focus of this project is developing new technology to improve both development and production of these products. To address product development issues, we […]

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