Prostaglandin E2 stimulates bone formation in vivo and exerts its effects through the EP4 receptor. Unfortunately prostaglandin E2 and agonists for the EP4 receptor also cause unacceptable systemic side effects which have limited their clinical use as anabolic agents. We developed novel bone-targeting prodrugs that can deliver EP4 agonists selectively to bone and liberate active […]

As the number of im/migrant women in British Columbia (BC) continues to grow – the majority of whom are of reproductive age- there is a need to ensure that im/migrant women have adequate access to healthcare, including sexual health services. While BC is one of Canada’s top destinations for im/migrants, robust evidence regarding im/migrant women’s […]

British Columbia’s sablefish fishery is among the most highly valuable fisheries in Canada. In the early 1990s, mainland inlets were closed to commercial fishing because young sablefish were thought to grow in these protected areas before moving to the offshore areas where the fishery operates; we will look at movement patterns of sablefish within BC […]

Conservancies are a new and unique type of protected area in British Columbia that explicitly recognizes First Nations’ rights to social, ceremonial and cultural uses of the area. Conservancies, and the Conservancy Management Plans (CMPs) that direct them, are informed by a Collaborative Management Agreement (CMA) that is negotiated on a government-to-government basis between the […]

Wheelchairs are one of the most important devices in rehabilitation that have immensely improved the quality of life for people with disabilities and impairments. Wheelchairs are subject to tips and falls, that can cause injuries. For a person who relies on a wheelchair for mobility, such injuries can have significant short and long-term effects on […]

The project includes three subprojects that are all of interest to Nokia to inform them of latest research in the area. The first subproject is to improve the features of the Ztitch mobile application that we developed, which has been downloaded more than 80,000 times. We will implement some algorithms to improve the stitching performance, […]

Fisheries are the main global threat to elasmobranchs (sharks and rays). Elasmobranchs commonly display conservative life history traits (slow growth, long life, late sexual maturity and low fecundity), making them extremely vulnerable to non-natural mortalities. However, there is significant variation, with some species exhibiting life history traits more resilient to exploitation. In order to assess […]

We propose to perform detailed studies that characterize chemically and biologically and the unaltered ancestral plant species of the Cannabis genus. Chemically, these studies will provide the chemotype profiles for each parental species for a spectrum of non-tetrahydrocannabinoid compounds. Biologically, these studies will provide the pharmacological profiles for each parental species. These data will enable […]

To an unprecedented degree in the history of HIV/AIDS, people with HIV/AIDS (PLHIV) are aging largely owing to the success of treatment. As a relatively new phenomenon, research on HIV/AIDS and aging is only just emerging, and remains largely epidemiological in focus. One leading epidemiological study called COAST comes from the B.C. Centre for Excellence […]

To an unprecedented degree in the history of HIV/AIDS, people with HIV/AIDS (PLHIV) are aging largely owing to the success of treatment. As a relatively new phenomenon, research on HIV/AIDS and aging is only just emerging, and remains largely epidemiological in focus. One leading epidemiological study called COAST comes from the B.C. Centre for Excellence […]

Through a review of existing anti-stigma campaigns targeting stigma towards people who use drugs (PWUD) and a series of focus groups conducted with marginalized PWUD, this community-based research project will explore how anti-stigma campaigns can be made more inclusive of all PWUD, especially those most severely impacted by stigma. The project is being guided by […]

The proposed project will focus on using new Optical Coherence Tomography techniques for non-invasive imaging of the anterior segment of the eye. In particular, our effort will be focused on using OCT methods to reliably image the lymphatics vessel network of the conjunctiva, which plays a major role in the progression and surgical intervention of […]