Retrospective molecular subtyping of pediatric medulloblastomas and the evaluation of BTIC gene signature in tumors with poor prognosis

Medulloblastoma is the most common brain tumor in children. It is treated with a combination of surgical resection, chemotherapy and radiation. Radiation to a child’s brain can have harmful side effects that may have implications in later development. We intend to use molecular gene expression to classify archived tumors into 4 subgroups with associated low […]

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Accelerating discovery through high-throughput experimentation and machine learning

Canonical methods of molecular discovery and reaction optimization rely on “trial-and-error” approaches and slow experimentation with low discovery rates. By harnessing high-throughput experimentation (HTE) with machine learning (ML) methods, artificial intelligence (AI) and robotics, we have the potential to dramatically accelerate the discovery and preparation of next generation molecules and materials. We will extract, unify, […]

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Accelerating discovery through high-throughput experimentation and machine learning – Year two

Canonical methods of molecular discovery and reaction optimization rely on “trial-and-error” approaches and slow experimentation with low discovery rates. By harnessing high-throughput experimentation (HTE) with machine learning (ML) methods, artificial intelligence (AI) and robotics, we have the potential to dramatically accelerate the discovery and preparation of next generation molecules and materials. We will extract, unify, […]

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Targeting the RSK Axis to Eliminate Medulloblastoma

Brain cancer is the second most prevalent cancer in children. Current treatment options are chemotherapy, radiation, and surgery, which either prolongs the child’s life for only two years or leaves them with negative side effects such as slowed development. Thus, there is a pressing need for new therapeutics. Mitacs Proposal Pambid, Mary One of the […]

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Improving the Accuracy of Data Loss Prevention Systems

Scotiabank employs teams of cybersecurity specialists across its global operations and partners with a variety of external organizations to prevent and investigate any electronic attempts to gain access to the Bank’s data. At the same time, employees are continuously educated and expected to look for warning signs and efforts to infiltrate that data as well. […]

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Understanding Stress Signaling in Childhood Cancers to Elucidate New Strategies for Therapy in Metastatic Childhood Cancers

The Sorensen laboratory-based Childhood Cancer Research Program is specifically focused on elucidating the genetic and biological determinants of the metastatic process in childhood cancer. Metastatic disease remains the single most dominant driver of adverse outcome in most childhood cancers, particularly in childhood sarcomas. Research in the program is dedicated to uncovering the mysteries of metastatic […]

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Centre for Operations Excellence Industry Projects 2019

The Centre for Operations Excellence Industry Projects 2019 consists of seven sub-projects sponsored by five different industry partners. Each sub-project represents an important challenge for its sponsor. These sub-projects include Extracting data from unstructured text of NOTAMs to assess relevance (Boeing 1), Developing a fix effectiveness engine to perform data-driven predictive maintenance (Boeing 2), Initial […]

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Conservation Policy for Effective Local Resource Governance: A Case Study in the Kailash Sacred Landscape Conservation and Development Initiative

This research project is part of a comparative study on conservation governance in two landscape conservation initiatives: the Tallurutiup Imanga National Marine Conservation Area in Nunavut, Canada and the Kailash Sacred Landscapes Conservation and Development Initiative in Uttarakhand, India. Hosted by the Wildlife Institute of India, the Uttarakhand component of this project aims 1) to […]

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Serum Protein and Antibody Interactions with Immunomagnetic Cell Isolation Particles

Immunomagnetic cell isolation particles are widely used to separate cells from complex, biological environments, such as blood, urine, or bone marrow. Cell isolation particles are typically decorated with specialized antibodies to bind to targeted cell surfaces via specific antibody–antigen interactions. These interactions can be disturbed by the presence of serum proteins, which are common constituents […]

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Evaluating the Impact of Robotics Education on Young Children’s Cognitive Development and Self-efficacy

Our project will be the first research in Canada that draws the techniques and resources from four disciplines – education, psychology, psychometrics and computer science – to investigate the effects of robotics education (RE) on child cognitive development, self-efficacy and enjoyment. Hence, our research findings will help Robokids School to understand the long-term effects of […]

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