Thousand Protein Multiplexed Mass Spectrometry Assay for Biomarker Discovery

  In recent years, the interest given to disease biomarkers has boomed. Biotechnology and pharmaceutical companies are exploring ways to use biomarkers to speed up the drug development process, as well as to rapidly assess a diseases state, staging, progression and response to therapy. Multiple reaction monitoring (MRM) Mass Spectrometry (MS) has been shown to […]

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New Orthogonal Polynomials and their Applications

  We propose development and validation of novel mathematical tools which can be used for information processing for object and/or model identification and detection within decision support systems (DSS) in various decision frameworks such as situation assessment and analysis, genetic modeling and analysis, medical imaging, etc. The project will have two main novel contributions: (1) […]

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Does the fetal short-term variability measure RMSSD reflect the fetal inflammatory status and can RMMSD be reliably recorded using a novel ultrasound fetal heart rate monitoring system?

  A certain number of newborn babies may suffer from infection. Many of such infections go unnoticed but may have negative effects on child's health. There is currently no satisfying means to detect such babies early on. We have learned that using information contained in fetal heart beats we might better predict if a yet […]

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Detection and quantification of organ toxicity biomarkers

In recent years, the interest given to disease biomarkers has boomed. Biotechnology and pharmaceutical companies are exploring ways to use biomarkers to speed up the drug development process, as well as to rapidly assess  diseases state, staging, progression and response to therapy. Multiple reaction monitoring (MRM) Mass Spectrometry (MS) has been shown to be well […]

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Realistic and high-performance rendering

State-of-the-art computer graphics technology allows for the generation of images and animations that border on photo-realistic quality; however, this level of fidelity is often reserved for feature-film productions where the time budget is much more flexible. In the case of interactive graphics, such as approaches that are used in video games, similar demands are made […]

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QU02 MRI: a new window on mitochondrial dysfunction in Alzheimer’s disease

This project seeks to develop new methods for imaging oxidative and vascular function in the brain. The methods under development are based on widely available MRI hardware, which will make them feasible for use in future clinical drug trials, an application that is of interest to the partner organization CQDM. Before the approach is ready […]

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Exploitation of special functions orthogonal on finite domains of 2D and 3D lattices-Fourier expansions of functions sampled on lattices

The advantages of digital data (signal functions) processing have made this technique a standard for processing real world analog data in many areas of life, from music industry to seismology. Stored digitally, the data also become less sensitive to physical limitations than their analog counterparts. Other advantages include straightforward low frequency filtering procedures (e.g. as […]

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Realistic and High-Performance Rendering Renewal

The goal is to investigate the realistic appearance models for complex reflectance properties, modeling reflectance, masking and inter-reflection at many scales. In the end, comparison and basis-space representation will be leveraged to develop an interactive rendering application for pre-visualization and in-game portrayal of complex materials.

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Automatic Genre Detection for Intelligent Audio Tools

MixGenius works on automated musical production by real-time musical genre detection. High accuracy of genre detection for a variety of sub-genres is required for quality production and has yet to be achieved. The project involves researching available real-time high-accuracy musical genre detection methods and improving upon them, extracting each genre’s audio features, calibrating the algorithm […]

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Peripheral contribution of dehydroepiandrosterone (DHEA) in the brain steroidogenesis

DHEA is a major neurosteroids precursor, and a decrease in its serum levels have been associated with neurodegenerative diseases, especially Alzheimer's disease. Little is known about steroid hormones localization and levels in the major functional areas of the human brain and which enzymes are involved in their synthesis and inactivation. We will investigate steroids levels […]

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Intermodal container allocation problem in rail yards

In this project, we propose to develop innovative methods to improve the efficiency of yard operations in intermodal terminals where containers awaiting to be loaded on the trains are temporarily stored. The management of yard operations involves allocating storage space to containers on the yard, and assigning cranes and/or other handling equipment to transfer the […]

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