Multiparametric Analysis of Brain & Lung Imaging from COVID-19 Patients

The intern will participate in NEUROCOVID19, a project studying how the COVID-19 virus can potentially infect and damage the brain. The intern will develop methods for analyzing magnetic resonance imaging (MRI) of the brain and of the lung, as acquired from people who are no longer infected, and people who were never infected. The intern […]

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Quo Vadis? Ontologies for Geospatial Question Answering and Consumer Behaviour

A geospatial query is a question where the concept of location is necessary for formulating the answer. Furthermore, we are not simply interested in spatial relationships, but also with the ways in which people can possibly move through space given the goals that they want to achieve. We therefore want to predict the behaviour of […]

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Modeling the phenotypic effects of neuromodulatory agents on human neuronal cells using cerebral organoids

Emerging therapeutic agents that function through the brain’s neurotransmitter systems have recently shown robust benefits in a number of otherwise challenging to treat neurological conditions including depression and post-traumatic stress disorder. The long-term changes that these agents induce within neural tissue is still however unclear. This MITSCS program aims to to use expertise in tissue […]

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Blocking assembly of glycosylphosphatidylinositol (GPI) anchors to inhibit growth and increase immunogenicity of human fungal pathogens

Fungal pathogens cause life-threatening invasive infections in humans. Despite all available treatments, mortality rates remain unacceptably high, on par with deaths caused by infectious diseases such as tuberculosis and malaria. Alarmingly, the emergence of drug-resistant fungi is reducing already limited treatment options. To address needs for new antifungal medications, Amplyx Pharmaceuticals has developed fosmanogepix, a […]

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DARSA (Deep-learning Assisted Radiological Software Application):Innovative Machine Learning approaches for Detecting Pathology inImages

Many aspects of healthcare are time consuming and error prone. Recently there has been great progress in using artificial intelligence to solve a number of problems. One of the best examples of this is image labelling using a type of neural network approach called deep learning. Recent research has shown that deep learning approaches can […]

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Explore Remote Virtual Technologies Using Real-time Very Long Baseline Interferometry (VLBI)

This program will cement Canada’s leadership in global Very Long Baseline Interferometry (VLBI), a key technology in radio astronomy and geodesy. In partnership with Thoth Technology Inc., our team of leading radio astronomers will (i) develop new capabilities to compress, transport, and process large amounts of data between geographically distinct locations to enable real-time VLBI, […]

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Epigenetic Regulators of Anticancer Drug Response

The effectiveness of cancer drugs depends on several factors which are governed by the genetic and ‘epigenetic’ code of cancer cells. The epigenetic code comprises those heritable modifications that bookmark DNA and DNA-associated proteins to guide the expression of genetic attributes without changing the DNA sequence. This epigenetic code is written, read, and erased by […]

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Feasibility of physiological assessment for objective confirmation of non-invasive electrical recruitment of the saphenous nerve

Overactive bladder, urinary urgency, affects 14-18% of the Canadian population and costs our health care system over $350,000,000 annually. Most current treatments require ongoing in-person support or have low adherence rates, enhancing greater strain on our healthcare system and economy. Non-invasive saphenous nerve stimulation (nSNS) overcomes these issues however there is currently no objective method […]

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City of Markham Inclusive Community Engagement Research Project

The proposed research project will explore how cities can do a better job at engaging everyone in the community planning process. This research will result in a collection of best practices and recommendations to help the City of Markham better engage with individuals in the community that are traditionally excluded from the planning process. This […]

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Integration of Safety Analysis into Model-Based Systems Engineering

In recent years, there has been a rapid advancement of technology and an increased use of computer models to develop aircraft and aircraft systems. Unfortunately, safety assessment procedures have remained largely document-based, and thus have struggled to keep up with such rapid design changes. The objective of this project is to develop a solution that […]

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Thin-film photocatalyst development for Solar-Driven GHG Conversion to Fuels

Solar-driven dry-reforming is an ideal solution for recycling greenhouse gasses (GHGs) while producing valuable chemical feedstock. These anthropogenic emissions of the GHGs are the leading cause of global climate change. Furthermore, these emissions are related to the manufacture of fuels and carbon-based products. Solar fuels technology addresses both of these issues. Solistra is developing photocatalyst […]

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