Modulation of human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) ion channels and transporter activity, measured by atomic absorption spectroscopy (AAS)

During human clinical trials, a large percentage of candidate drugs fail because they are unsafe or ineffective. Even when preclinical cell and animal studies seem positive, problems occur because drugs tested with these models are often not predictive of what happens in humans. Many drugs, including non-cardiovascular drugs, target ion channels of the heart (membrane […]

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