Machine learning-based optimization of a small-molecule suppressor of the cellular prion protein

A reduction in the levels of the cellular prion protein (PrPC) is expected to ameliorate cellular toxicity in both Alzheimer’s disease (AD) and prion diseases. The latter are invariably fatal diseases that include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy (BSE), also known as ‘Mad Cow Disease’, in cattle. To identify a rational method […]

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