Peripheral contribution of dehydroepiandrosterone (DHEA) in the brain steroidogenesis

DHEA is a major neurosteroids precursor, and a decrease in its serum levels have been associated with neurodegenerative diseases, especially Alzheimer's disease. Little is known about steroid hormones localization and levels in the major functional areas of the human brain and which enzymes are involved in their synthesis and inactivation. We will investigate steroids levels […]

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