Developing computation tools for the rational design of cyclic peptide therapeutics

The majority of drugs that enter the market are discovered by screening millions of random chemical compounds until a desired effect is achieved. With the recent explosion in available biological data and raw computing power, it is now possible to develop drugs through bottom-up design rather than trial-and-error testing. Bottom-up drug design has the potential […]

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Engineering WD40 Domain-Mediated Protein-Protein Interactions in DNA Repair for Cancer Therapeutics

Current cancer therapies rely on toxic chemotherapeutic agents that lack the potency and selectivity of protein-based therapy. Consequently, new technologies to systematically target cancer signaling pathways at the protein level are urgently needed. Dr. Zhang has developed a platform that consistently and successfully produces quick and cost-effective protein-based therapies that are both highly-binding and specific […]

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