On estime qu'un tiers de la population mondiale est infecté du Mycobacterium tuberculosis. Face à l'émergence de souches résistantes aux médicaments, l'Organisation mondiale de la Santé a déclaré que la tuberculose constitue une urgence de santé mondiale. L'UDP-galactopyranose mutase, une enzyme essentielle pour la croissance de la bactérie de la tuberculose et pour les infections […]

Ce projet combinera la biochimie structurale et les simulations moléculaires haute performance afin de produire d'importantes nouvelles connaissances qui serviront au développement de la prochaine génération de ligands pour les vaccins. La collaboration entre les deux partenaires – industriel et universitaire – crée une occasion idéale de marier des démarches théoriques et expérimentales en vue […]

Les maladies diarrhéiques constituent un grave problème mondial, en particulier dans les pays en développement. Le Shigella flexneri Y, l’espèce de Shigella la plus mortelle, est endémique dans la plupart de ces pays. Un anticorps, le SYA/J6, a été élaboré pour combattre le Shigella flexneri Y. Des études ont démontré que le MDWNMHAA est un […]

Zanidatamab is an antibody being evaluated in clinical trials to treat breast cancer, biliary tract cancer and gastroesophageal adenocarcinomas linked to the overabundance of a protein known as HER2. Zanidatamab was developed to bind to two copies of HER2 in tandem instead of one, increasing its binding affinity and improving its inhibition of HER2 tumor-promoting […]

The proposed project combines structural biochemistry with high-performance molecular simulations to generate valuable insight into the development of the next generation of ligands that can be used to develop vaccines. The collaboration between the academic and industry partner creates an ideal opportunity to combine theoretical and experimental approaches for better lead generation and development of […]

It is estimated that one third of the world’s population is infected by Mycobacterium tuberculosis. With the emergence of drug resistant tuberculosis, the World Health Organization has declared tuberculosis a global health emergency. UDP-galactopyranose mutase, an enzyme essential for tuberculosis bacterial growth and infection, will be studied by a protocol which combines advanced NMR and […]

Diarrhoeal diseases pose a serious global problem, especially in the developing world. Shigella flexneri Y, the most deadly species of Shigella, is endemic in most developing countries. An antibody, SYA/J6, against Shigella flexneri Y was developed. Studies have shown that MDWNMHAA is a weakly immunogenic peptide against the antibody SYA/J6. The research team at Zymeoworks […]