Direct Astrocyte-to-Neuron reprogramming using Self-amplifying RNA and RNA-based circuits

With an aging population, age-related neurological disorders like Alzheimer’s and Parkinson’s diseases, as well as stroke, are increasing. These conditions involve critical neuron loss, yet the brain’s ability to replace neurons is highly limited. Current regenerative therapies, such as neural stem cell stimulation or neuron transplants, show promise but face challenges in manufacturing and patient […]

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Statistical Shape Modelling in Ankle Osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease causing pain and disability affecting weight-bearing joints. Unlike knee and hip OA, ankle OA is linked to trauma and remains under-researched despite its impact on mobility and quality of life. Joint kinematics play a key role in OA progression, as altered movement patterns accelerate cartilage degeneration by changing […]

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Unpublished Works for Cello Solo of the Mexican Avant-garde

My research project into Mexican Avant-garde music for solo cello (written between 1962 and 2012) attempts to define and evaluate what Mexican Cello Solo Music is and how it has evolved over the years to the point of exerting a significant influence on the universal cello solo repertoire. (This discipline belongs to a category of […]

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EcoFusion : biocomposites innovants à base de biochar et PLA

Le projet de recherche proposé a pour but de développer de biocomposites durables en combinant l’acide polylactique (PLA) et le biochar, un matériau issu de la pyrolyse de résidus forestiers. Face aux enjeux environnementaux liés à la pollution plastique, ce travail cherche à apporter des solutions, à la fois innovantes et durables, pour la conception […]

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Estimating brain tissue deformation from a microscope video

Epilepsy, a neurological disorder impacting millions worldwide, often requires precise surgical interventions when medications fail. The surgical procedure demands high levels of skill to remove the lesion causing epilepsy while minimizing damage to surrounding healthy tissues. Current training methods for such intricate procedures are insufficient, relying heavily on subjective assessments and limited hands-on opportunities, which […]

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Interactions entre la végétation boréale alluviale et la dynamique fluviale en contexte de pergélisol sur la Beaver Creek River, Yukon

Ce projet de recherche vise à étudier les impacts du changement climatique sur la Beaver Creek River, au Yukon, au Canada. Dans cette région froide, le pergélisol (sol gelé en permanence) se dégrade sous l’effet de l’augmentation des températures, particulièrement marquée aux niveau des pôles, ce qui peut fragiliser les berges des rivières, modifier les […]

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Effect of altitude on cardiovascular responses to voluntary apnea in Nepali Sherpa

Our lab has demonstrated that voluntary apneas (i.e., breath-holds) at high altitude cause decreases in heart rate in lowlander populations. Apneas at altitude also cause cardiac arrhythmias in a majority of lowlanders. Unlike lowlanders, native highlanders (e.g., Nepali Sherpa) do not get the same decreased heart rate and cardiac arrhythmias during voluntary apneas at high […]

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Evolutionary Significance of Hybrid Zones on Avian Biodiversity from the Neotropics

Tropical forests house an exceptionally high biological diversity and despite great interest in factors that might drive the formation of high species richness, little is understood about how this diversity arose. In the Neotropics, rivers appear to delimit the geographic ranges of closely related avian species, and are generally believed to have been important in […]

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Participation in the operation of the biobank at the USask Biobank

The USask biobank currently specializes in oncology specimen collection. We cover all steps from biospecimen sample collection (biopsy, tissue, blood and ascites fluids), processing, quality control and storage. We also coordinate new release samples for the USask and Pan-Canadian project research teams. All patient data, samples and associated data must be captured, traceable and updated […]

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Analyse de la cinématique des chutes en escalade de bloc et des conditions d’impact sur les matelas de protection

Ce projet de recherche vise à analyser les chutes en escalade de bloc et les conditions d’impact sur les matelas de protection. Après une première étude menée en France auprès d’un public généraliste, cette nouvelle phase se concentrera sur un panel de grimpeur.euses canadien.ne.s, comprenant des expert.es et jeunes expert.es. L’objectif est d’intégrer les spécificités […]

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