Understanding the stability profile of a product, whether a consumer packaged good or a pharmaceutical drug product, is key to ensuring the consumer has a safe and effective product. In the pharmaceutical realm, the internationally accepted approach to stability testing is codified within the International Conference on Harmonisation (ICH) Guidance: Q1A(R2) (Stability Testing of New […]

Many rural regions do not have a sufficient labour force providing the skills that rural businesses need. Many job vacancies go unfilled or are filled by less than ideal candidates. This research looks at strategies to attract and retain the workers that Ontario rural communities need to generate economic development and vitality. By engaging local […]

Urgent calls exist to address the mounting crisis of mental illness, and in particular posttraumatic stress disorder (PTSD), among public safety personnel (PSP; e.g., firefighters, police, paramedics) in Canada. Critically, PTSD is associated with alterations in cognitive functioning (e.g., poor memory and attention) that disrupt the ability of PSP to engage in activities such as […]

Rational protein design has had a tremendous impact on pharmaceutical, agriculture, and chemical industries over the past 30 years, by focusing exclusively on individual proteins and their intrinsic activities. The next generation of protein design tasks will seek to modify function inside living cells, competing and interacting directly with pre-existing cellular machinery. Modifying systems in […]

Risk aggregation is omnipresent in insurance applications. A recent example, borrowed from the modern regulatory accords, is the determination of the aggregate economic capital and its consequent allocation to risk drivers. A more traditional illustration of the importance of risk aggregation in insurance is the celebrated collective risk theory that dates back to the early […]

Recreational river waves are gaining more and more popularity, but there is not enough academic research to support them and very few companies around the world can artificially create them using adjustable structures in rivers. Surf Anywhere, the Calgary-based partner organization in this research, is one of those few companies that has completed and is […]

The objective of the proposed internship is to help support the launch of disability inclusive content for an app created by ParticipACTION, Canada’s leading non-profit physical activity organization. The goal of the content is to motivate inactive Canadians with a disability to sit less and move more, with the aim of achieving Canada’s Physical Activity […]

Client risk is one of the major decisions in wealth management. Many of the client risk assessment methods that are used in wealth management are in-house developed on an ad-hoc basis. The objective of this research is to assess the validity and reliability of the risk assessments methods developed by RiskMetrics. This study will be […]

Structural integrity assessments play a key role in ensuring the safe service of oil/gas pipelines. In recent years, significant developments in pipeline strain-based design have taken place to account for the large plasticity involved in the installation and operation of pipelines. However, current methodologies cannot properly address the effects of anisotropic material properties and weldments […]

The COVID-19 pandemic reminds us that, first, global pandemics are significant threats to population health and material standard of living and, second, evidently not enough is being done to prevent pandemics. Future pandemics are likely if the system of pandemic preparedness is not improved. The first step to ensure we are ready for the next […]

The COVID-19 pandemic led to an increased demand for disinfection solutions, including ultraviolet C (UVC) light technologies. UVC works by inactivating microorganisms and show a strong potential to break the chain of infection in hospitals and public settings. CleanSlate and the University of Toronto are exploring this potential by characterizing how the virus that causes […]