Tissue transglutaminase (TG2) is a protein that is able to mediate the cross-linking of other proteins. The unregulated activity of TG2 is implicated in fibrosis, celiac disease as well as cancer cell survival. Blocking this activity has been shown to decrease tumour size and growth in mice. We have previously designed small molecules that are […]

Glycoconjugate vaccines have shown efficiency to control infectious diseases and hold great promises in cancer immunotherapy. Nonetheless, there is an important need to identify novel immunostimulating carriers for carbohydrate antigens as well as to optimize the currently used protein carriers. This Mitacs project aims at developing versatile biochemical approaches and technology for the design and […]

Molecular You is a health-tech start-up on a mission to help people live longer, healthier lives. Using a new type of blood test, we’re able to give people unparalleled insight into their health and make precise diet, exercise and supplement recommendations to help them live longer healthier lives. The product consists of a mobile application […]

Electronic Health Records (EHR) are the digital collection of a patient’s health information. EHRs can benefit clinicians, healthcare administrators and patients through the use of information technologies to manage various aspects of healthcare. These investments require sustained efforts to engage a multitude of stakeholders, and allow them to seek opportunities to automate, integrate and digitize […]

Total hip and knee replacement surgeries are the second and third most common surgical procedures in Canada, respectively. Opioid analgesics are routinely prescribed to manage pain after these procedures, making orthopaedic surgeons the third-highest opioid prescribers in Canada. However, opioids are not typically more effective than alternatives (e.g., NSAIDs) and are associated with addiction, overdose, […]

This research project aims to study the factors which can influence engagement in physical activity in older adults and how it is linked to health. Using data from multiple countries and collected over periods of up to 12 years the research project will look at the influence of socioeconomic and environmental factors on this relationship. […]

This research aims to: (1) determine how the brain, heart, vessels, lungs, and muscle oxygenation regulation in female and male frail older adults. In study #1, participants will perform three postural transitions: (a) sit-to-stand, (b) lie-to-stand, and (c) lie-to-sit, and three identical constant workload walking tests. The autonomic (brain, e.g., sympathetic and parasympathetic activity), cardiovascular […]

Les milieux de travail comportent souvent des risques qui peuvent nuire à la santé des travailleurs tels que les risques chimiques ou biologiques et les risques psychosociaux (RPS). Ces derniers correspondent à des mauvaises conditions de travail (ex. : grande charge de travail, manque de reconnaissance, conflits, etc.) et peuvent amener au développement d’atteintes à […]

The project goal is to complete a community-wide vulnerability capacity assessment to gain a deeper understanding of the populations that require access to Emergency Social Services (ESS) during a large scale emergency, including the potential impacts of emergencies on these populations. This will aid in resource allocation and priority setting to better prepare for and […]

Standard cognitive assessments are normally administered over pen-and-paper or desktop computers. Although these tests are accessible, they are often administered by a trained professional to ensure protocol adherence, and shorter tasks are often repeated many times to mitigate the impact of anomalous trials. These considerations render the current practices costly and time-consuming. For this proposal, […]

Having unmet physical and social needs, such as being food insecure or living in unstable housing, is associated with a number of negative outcomes, including poor health. One common approach to addressing unmet needs includes sharing referrals to relevant social and community resources, which is a service that the 211 Ontario helpline provides. How close […]

There is a significant waitlist for clients experiencing cognitive impairment (which can be due to a number of reasons) to receive clinical care. Symptoms may include impairments to attention and executive functions (higher-level cognitive abilities supporting focused task performance) or functional (e.g., vocational or activities of daily living); symptoms may be exacerbated in those who […]