Prescribers rely on guidelines for appropriate use and prescribing of opioids. Currently, there are no risk prediction calculators available to quantify the risk of prescribing an opioid that uses a patient’s history and drug utilization pattern. Machine learning algorithms offer an opportunity to perhaps develop such a risk calculator as a result of the large […]

While efficacious treatments are available for HIV, they require lifelong adherence and can have harmful effects over time. Therefore, developing novel treatments and a preventative vaccine remain critical. While most vaccine attempts to date have been largely unsuccessful, identifying new targets on the virus, may provide novel avenues for HIV vaccines and therapies. Integrin alpha […]

Breast cancer affects 1 in 8 women during their lives and is the second-leading cause of female cancer related deaths. The ideal treatment is breast-conservation surgery during its early stage to remove the cancer while conserving healthy parts of the breast. With current resection methods, on average, one out of every three women undergoing breast-conservation […]

La maladie de Parkinson touche plus de 1,5% des personnes de plus de 65 ans et jusqu’à 90 % des personnes atteintes développent des difficultés à avaler ou à s’exprimer au courant de leur maladie. Ces difficultés nuisent aux relations sociales des personnes qui vivent avec cette maladie. Des thérapies en orthophonie peuvent aider à […]

An important challenge in developmental psychiatric research is to understand which are the neural mechanisms underlying language acquisition and speech comprehension. Auditory entrainment is the mechanism by which the brain faithfully entrains electrophysiological activity to rhythmically modulated stimuli, and it is seen as the mechanism that the listening brain use to attune to acoustic regularities […]

To an unprecedented degree in the history of HIV/AIDS, people with HIV/AIDS (PLHIV) are aging largely owing to the success of treatment. As a relatively new phenomenon, research on HIV/AIDS and aging is only just emerging, and remains largely epidemiological in focus. One leading epidemiological study called COAST comes from the B.C. Centre for Excellence […]

To an unprecedented degree in the history of HIV/AIDS, people with HIV/AIDS (PLHIV) are aging largely owing to the success of treatment. As a relatively new phenomenon, research on HIV/AIDS and aging is only just emerging, and remains largely epidemiological in focus. One leading epidemiological study called COAST comes from the B.C. Centre for Excellence […]

As a result of increasing obesity, non-alcoholic fatty liver disease (NAFLD) is now the most common chronic liver disease. Non-alcoholic steatohepatitis (NASH) is the pathogenic form of NAFLD and can progress to cirrhosis and need for liver transplantation. There is currently no Health Canada-approved therapy for the treatment of NASH. The intestinal microbiome has been […]

Diets which reduce carbohydrate intake and increase protein intake, such as Atkins diet, are popular and effective for weight loss. However, such diets may negatively affect cardiovascular health by increasing atherosclerotic plaque formation, and overall lead to higher mortality. Vuckovic and Bergdahl previously used mouse model that mimics spontaneous formation of atherosclerotic plaques in humans […]

Sleep disturbance is one of the major complaints in patients after major surgery, which can impair to postoperative recovery. Exercise may be an effective non-pharmacological intervention to improve sleep for patients with advanced cancer. The main objective of this proposal is to evaluate the relationships between physical exercises and sleep parameters before surgical procedures and […]

Les projets visent, dans les deux entreprises ciblés, soit des PME, à : • contribuer par diverses analyses, recommandations et implantations, à améliorer sensiblement le système de gestion de l’innovation dans ces entreprises, • et surtout à intégrer le système de gestion de l’innovation à la stratégie d’affaires et aux activités régulières de l’entreprise (stratégie, […]

Through a review of existing anti-stigma campaigns targeting stigma towards people who use drugs (PWUD) and a series of focus groups conducted with marginalized PWUD, this community-based research project will explore how anti-stigma campaigns can be made more inclusive of all PWUD, especially those most severely impacted by stigma. The project is being guided by […]