Bipolar disorder (BD) is a chronic psychiatric disorder with peak age of onset between 15 and 25 years. In clinical practice it takes over a decade from initial symptom presentation to accurate diagnosis, with such delays being linked to a range of adverse consequences. Therefore, finding early markers of vulnerability is essential. Familial history (i.e. […]

Girls with Turner syndrome (TS), a chromosomal condition in which a female has complete or partial absence of the second sex chromosome, present a unique group of patients, with an increased risk of cardiovascular disease. Since the mid 1900s extensive research has led to advancements in the treatment of Turner syndrome: growth hormone therapy can […]

In the field of childhood disability research, there is an important shift towards engaging with patients and families who have the lived experience of a disability. To build authentic relationships with family partners, there should be clear communication throughout all study phases. To our knowledge, the Involvement Matrix is to the only tool to guide […]

People with chronic lung diseases must breathe with more force and with more breaths because their diseased lungs do not exchange oxygen as well. This occurs in interstitial lung disease, when the lungs are stiffer and in chronic obstructive pulmonary disease, when the airways are obstructed due to phlegm and swelling. The breathing muscles in […]

The group in Canada has extensively studied the factors (known as biomarkers) that can influence how people respond to anti-psychotic drugs, including if patients will develop side-effects. Our group in Liverpool has experience with compiling and analysing the large amounts of evidence required to prove a link between the biomarkers, and the patient’s response. The […]

In Senator Kirby’s 2006 report, Out of the Shadows at Last, children’s mental health was labeled the “orphan’s orphan” of Canada’s health care system. For over two decades, the systems-of-care philosophy in children’s mental health has recognized the need to respond to a fragmented service system through greater integration and coordination. Continuity of care, which […]

As Canada’s population continues to age, social isolation among older persons is being increasingly recognized as a concern. Social isolation affects over 30 percent of older adults and is associated with a range of negative health outcomes, from loneliness and depression to increased mortality. The overarching objective of this project is to identify promising practices […]

L’entérocolite nécrosante (NEC) est la plus commune et la plus meurtrière des maladies inflammatoires de l’intestin. Elle affecte 5 à 10 % des enfants prématurés ayant un poids inférieur à 1500 g. Le lait maternel constitue l’approche la plus efficace pour prévenir ou traiter la NEC. En effet, il a été montré que l’alimentation avec […]

The goal of the project is to develop relationships between academic and non-academic partners to gain insight and knowledge that can be used to inform the Athletes Embodied program. This initial partnership is the first step in establishing an effective and feasible program to reduce body image concerns in girls’ sport, enhance sport experiences, and […]

A first principles approach to molecular dynamics is crucial to understanding photo-chemical reactions. These reactions take place involving multiple electronic states, in other words, they undergo non-adiabatic dynamics. The problem is analogous to the many body problem where significant entanglement between the motion of electrons and nuclei is present. In this project we will develop […]

When people seek help from a social service, the assistance they need may be best provided by another service in the community. In these cases, they should be referred to the appropriate service. At this stage, things sometimes go wrong: Sometimes the service agent misunderstands the person’s needs or misunderstands the kind of help provided […]

Epilepsy-related sudden death occurs following uncontrolled recurrent seizure which are usually non-responsive to antiepileptic drugs. These patients found dead in bed usually following heart and respiratory arrest. It is not known whether seizure-affected brain regions regulating cardiorespiratory function play a role in this complication and if so, what is the mechanism underneath in order to […]