Apelinergic system as a promising target for myocardialdysfunction and shock

Cardiovascular disease and sepsis are two of the biggest public health problems in North America. Increasing evidence further suggests they are linked. Recent studies in human healthy volunteers and in chronic heart failure patients have highlighted the apelin system as a potential target for drug development. We therefore propose to fully validate pre-clinically the potential of apelin as a new target for cardiovascular disease and septic shock.

Pharmacological and phytochemical characterization of immunomodulatory polysaccharides from American ginseng

Ginseng is a medicinal plant with a long history of traditional use. The medicinal properties of ginseng root have been attributed to two main classes of chemical compounds: ginsenosides and polysaccharides. While much is known about ginsenoside pharmacology, less is known about polysaccharide pharmacology. One of the most important properties of ginseng root polysaccharides is their ability to stimulate the immune system.

Transdermal delivery of peptide hormones to treat tibial bone stress fractures using DiffusiMax liposomal cream base

The goal of this Mitacs research proposal study is to develop and apply experimental methodology for transdermal delivery of bone-targeting peptide hormone drugs. We aim to deliver these compounds using an appropriate hydrophilic-hydrophobic Diffusimax liposomal drug delivery cream base to anatomically superficial bone, at the sites of stress fractures (also known as “shin-splints”) in order to trigger bone repair, reduce pain burden, and to minimize possible side effects if those drugs were used systemically.

Production of bioactive peptides through high ydrostatic pressure assisted enzymatic digestion of egg white

Egg yolk contains IgY antibodies that target various infectious disease and food allergens. IGY Inc is a company focused on utilizing chicken immune system for antibody production. IgY antibody contains 0.64% of total wet egg yolk, after cracking each egg IGY Inc generates 60-70g of liquid egg white which has a low commercial value. Egg white is a rich source of dietary protein and also known for its biological activities. Therefore the primary objective of this study is to develop a pragmatic technique to hydrolyze egg white to produce peptides with biological activity.

The Role of Cannabinoid Receptors in Craniofacial Pain

Pain in the craniofacial region is one of the more complex and difficult to treat conditions for patients and clinicians. Current treatments are complicated by limited efficacy and considerable side effects. Many of these conditions show greater prevalence in women than men, but there is a lack of basic research utilizing female animals. Recent advances
in cannabinoid pharmacology have renewed hope in cannabis-based treatments for chronic pain. However, whether the endocannabinoid system can be recruited to treat specific craniofacial pain conditions remains unclear.

Synthesis & Development of Nano and Microsponge Formulations for Treatment of Osteoarthritis

Osteoarthritis is a slow and progressive degenerative joint disorder, and is the most common form of arthritis, causing a significant reduction in the quality of life of afflicted individuals. A common treatment for this disease is to inject corticosteroids, such as triamcinolone acetonide (TA), directly into affected joints, which treats the joint inflammation that causes pain, swelling and reduced mobility. However, the effect of these drugs is short lived due to the rapid clearance of the drug from the joint synovial fluid.

Somatostatin Receptor Mediated Modulation of Epidermal Growth Factor Receptors Signaling

The work proposed here is based on a novel and innovative approach which has not been addressed till today. We propose that developing a combined therapy to inhibit ErbBs and activate SSTRs, might be useful approach to control tumor progression and better hormonal therapy response in breast cancer. The outcome of the present study first, will uncover novel molecular and cellular mechanisms for SSTR and ErbBs functional interaction in pathophysiological conditions such as in breast cancer.

Producing bioactive peptides from left-over proteins of egg yolk after IgY extraction

Chicken egg yolk contains IgY antibodies that target various infectious disease and food allergens. IGY Inc is a company focused on utilizing chicken immune system for antibody production. Their innovative products have applications in food processing, therapeutics and diagnostics. IgY antibody contains 0.64% of total wet egg yolk and after extracting the antibodies, the leftover egg yolk is a material of low commercial value. Egg proteins are well known for its dietary value and also a rich source of bioactive peptides with anti-oxidant, anti-inflammatory activities.

Preclinical characterization of medical marijuana cultivars with therapeutic efficacy and low side-effect liability

Medical marijuana describes the legal use of cannabis plants for treating health-related issues. In Canada, there are currently about 40,000 medical marijuana users, and this number is expected to increase by over 1000% during the next decade. The large majority of patients use medical marijuana for its psychological effects, such as for anxiety, depression, pain and insomnia. There is a concerning lack of knowledge about the effects of different strains (“cultivars”) of medical marijuana, including both therapeutic effects as well as unwanted side-effects.

Investigating the effects of ?-adrenergic stimulation on IKs channel trafficking in cardiac myocytes using total internal reflection fluorescence (TIRF) microscopy

Cardiac arrhythmia is an electrical disturbance in the heart which can cause a variety of potentially life threatening conditions. Arrhythmias are due to malfunctions in the protein channels, which in turn alter the bioelectric currents signaling each heartbeat. A key channel responsible for terminating the electrical signal is the voltage gated potassium channel, IKs. During an adrenaline spike associated with the fight or flight response, there is an increase in IKs activity although the mechanism is not well understood.