Surgical prehabilitation of cancer patients undergoing surgical resection. Modalities to mitigate the level of anxiety and depression prior to surgery

There is emerging evidence from studies at the Montreal General Hospital supporting the effect of prehabilitation (also referred to as preoperative conditioning) on postoperative outcomes. Increasing physical fitness and optimizing nutrition in cancer patients before surgery can help patients feel physically stronger, return to their community functions sooner and potentially undergo adjuvant cancer treatment earlier than expected.

Robust and Automatic Knee Cartilage Segmentation on MRI Images Segmentation robuste et automatique du cartilage du genou sur des images d'IRM

In order to produce orthopedic knee prostheses for a patient, it is necessary to produce an accurate three-dimensional model of the knee cartilage. The overall goal of the project is to develop a new segmentation method of knee cartilage on MRI images that is both automatic and robust. Laboratoires Bodycad inc. is currently developing innovative technology for orthopedic domain. In this way, the company is a leader for image processing, CAD software development, and manufacturing domains.

Predictive Analytics and Applications for Clinical Support in Orthopaedics

Nova Scotia is one of the oldest demographics in Canada, with increasing rates of total knee arthroplasty (TKA), yet the identification of high-risk surgical TKA candidates prior to surgery at a patient-level remains inconclusive, limiting our ability to improve care management. The objective of this research is to explore Nova Scotia’s rich and comprehensive research and clinical databases related to osteoarthritis and TKA, and identify linkages between patient-specific factors, treatment options, and health outcomes, through personalized medicine analytical modeling.

Rapid Access to CT to Streamline Emergency Care

Since 2011, radiologists at Royal Jubilee Hospital (RJH) and Victoria General Hospital (VGH) have piloted a “Rapid CT” (CT = Computed tomography) program to provide same-day CT scans for patients referred directly by participating community physicians, with the intent of avoiding unnecessary ED (Emergency Department) visits. This research will test the hypothesis that the Rapid CT pilot project has reduced costs by reducing ED visits.

Agent-based scheduling in community health care

In this project, the intern will design a community health care scheduling system for the allocation of home visits to care givers in community health care. The system adopts an agent-based distributed system architecture which take patients scheduling preferences on time, location and care givers into account when assigning care givers to home visit appointments. In addition, the system will also provide care givers with the opportunity to express their preferences and availability constraints in taking service appointments.

Characterization of a senescence response that occurs during androgen-depletion therapy in prostate cancer ce

Prostate cancer (PCa) is the most frequently diagnosed cancer in Canadian men and the third deadliest. If the majority of PCa are well treated using first line treatments like surgery, radiation and/or androgen deprivation therapy (ADT), a proportion of cases (10%) progress to metastatic cancer resulting in more than 4 000 deaths annually in Canada. Improving the efficacy of first line treatments is a challenge to prevent the apparition of more aggressive PCa metastatic stage. Cancer therapies do not necessarily trigger simple cancer cell death.

Establishing baseline heart rate variability profiles for exercise prescription and health monitoring among Special Olympics athletes

The change in the time intervals between adjacent heartbeats is known as Heart Rate Variability (HRV). The HRV of a well-conditioned heart is generally large at rest, whereas low HRV has been associated with adverse outcomes/conditions, including congestive heart failure, diabetic neuropathy, depression, and hospital admissions.

Biomarkers of Spinal Cord Injury

In this project, we will establish biomarkers that objectively reflect the severity of injury, measure its progression, and predict neurologic outcome after acute spinal cord injury (SCI). This will be accomplished by comprehensively analyzing blood and spinal fluid samples from acute SCI patients. In addition, we will conduct a parallel experimental study in a large animal model of SCI with a similar analysis of blood and spinal fluid samples.

Development of a novel robust clone for the manufacturing of AVID100 biosimilar

AVID100 is an antibody-drug conjugate (ADC) against a validated cancer target that is undergoing IND-enabling studies. Phase I clinical trials are scheduled for late 2016. The monoclonal antibody (mAb) portion of the ADC is currently manufactured using a recombinant CHO clone that fails to meet industrial production yield standards. In order to support clinical phases II and III as well as commercial supply a higher-expressing cell line must be developed. MAb product characteristics will need to be similar to the current clone, namely with regards to the N-glycan composition.

Optical liquid fingerprinting for dynamic process monitoring in nanofabrication

Color-based sensing enables sensors to be utilized in more places and by more people, particularly those who do not have access to or required training for sophisticated and expensive sensing technologies. This cost-effective sensing process is based on the change in an indicator’s color in response to the stimulation that is being sensed. This project seeks a novel
application for a color-based sensing method (Optical Liquid Fingerprinting technology), previously developed by the project’s partner organization.

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