Clinical experience demonstrates that canine patients commonly suffer from neuropathic pain and little is known to address this issue. Our study aims to investigate different tools for the diagnosis and treatment of neuropathic pain. Forty dogs with naturally-occurring neuropathic pain will be included in a prospective, randomized, masked clinical trial using appropriate inclusion and exclusion criteria.
Treatments that involve activating a patients own immune system, immunotherapies, are becoming important cancer therapies. Unfortunately, doctors dont always know the best way to combine these therapies to best treat patients and the current tools they have to evaluate treatment success dont work well for immunotherapies. Molecular imaging, particularly magnetic resonance imaging (MRI) or positron emission tomography (PET) can help researchers learn more about how these therapies work and how best to combine them.
The prevalence of diabetes is growing rapidly and currently, over 60 million people worldwide use insulin treatment to manage their diabetes. However, insulin treatment can result in hypoglycemia or low blood sugar levels. To date only retroactive treatments are available to treat hypoglycemia, which affects an individuals quality of life and increases the likelihood of recurring bouts of hypoglycemia as well as development of cardiovascular or renal disease.
The aim of the proposed research is to investigate the cellular mechanistic effects of supplementation with a hypocaloric meal replacement product (Optifast-900; Nestlé Canada) containing cysteine and glycine, which are amino acid precursors of the antioxidant glutathione. Impaired cellular glutathione redox normally occurs with aging and metabolic disorders, however, this study will focus on a population in which we have previously observed impaired muscle cellular glutathione redox and slow weight loss during the exclusive dietary consumption of Optifast-900.
University of British Columbia and Amgen British Columbia (ABC) will collaborate to develop a safe and efficient lipid-based vaccine delivery system that can be used in laboratory animals to enhance the production of specific antibodies against difficult targets. These antibodies can be further screened and characterized for treating various diseases in humans.
Aptamer based sensor development can be challenging. While aptamer selection has provided a very useful method of producing molecules that selectively bind compounds of interest to the fields of public health, regulatory control and legal enforcement, the steps required for incorporation of aptamers into sensors are not trivial. Specifically, gaging how well aptamers bind their target and determining how aptamer modification for sensor incorporation may affect their properties have slowed down the commercialization of this technology.
The vision of this proposed project is to design and build a collaborative service robot that will help people with developmental disabilities (DD) reach their personal goals and achieve greater independence, using existing and new technologies. This will allow the industry partner, JDQ, to advance the type of services provided to people with DD and their caregivers in a group home environment, through its partnership with Developmental Disabilities Association (DDA).
The American Speech-Language-Hearing Association (ASHA) recommends to include electrophysiological measures in their auditory processing disorder (APD) assessment battery. But few audiologist include electrophysiological assessment due to lack of evidence. There is strong evidence of auditory brainstem abnormality in these children. However, very less is understood about stimulus processing within the cochlea, auditory brainstem coding in noise (ipsilateral) and the thalmocortical functioning in APD children.
Work-related morbidity and mortality not only result in loss of time at work, reduction of the overall productivity, increase of the additional hiring and training costs and increased use of medical and welfare services, but it also results in suffering and hardship for the worker and his or her family. The Workers’ Compensation Board of Saskatchewan (WCB-SK) strives to advance scientific and technical knowledge in understanding the occupational injury and fatality risks to reduce the incidence or severity of injury in Saskatchewan.
NeuroRx is an imaging contract research organization (CRO) specialized in the central nervous system (CNS) that utilizes state-of-the-art digital image processing techniques to produce accurate and precise outcome measures for clinical trials of drugs in development. Prior to analysis, all scans must pass Quality Control (QC). The goal of this project will be to incorporate advanced computer algorithms to automatically classify the quality of high-resolution structural brain Magnetic Resonance Images. The advanced computer algorithms will include deep learning algorithms.