Utilization of Asparaginase-expressing yeast for the treatment of leukemia

Acute Lymphocytic Leukemia (ALL) is a common form of leukemia that affects approximately 3 people per 100,000 individuals, and is the most common form of cancer in children and adolescents. Current therapies are effective in children, however, treatment success in infants, adolescents, and adults needs improvement. Indeed, there is a need for new chemotherapeutic drugs and drug formulations that can improve survival rates in susceptible age groups, reduce relapse rates, and improve outcomes in relapsed patients.

Design of seismic force resistant cross-laminated-timber walls and interior partition walls - year 2

The structural use of timber in North America is largely limited to low-value commodity products used in low-rise residential light-frame construction. There exists, however, much greater potential for timber to be used as a structural material. One solution involves the notion of “mass-timber” such as cross-laminated timber (CLT) panels. The prospect of building larger timber structures creates challenges, one of them is that lateral forces created by wind and earthquakes increase. Two of the questions that arise are: 1) what is an efficient method for hold-downs for CLT panels?

Identification of transcription factors involved in cannabinoid biosynthesis and glandular trichome formation - Year two

As an important medicinal plant, Cannabis sativa produces bioactive molecules that provide symptom relief for conditions such as severe cancer pain, nausea and vomiting associated with chemotherapy. The cannabinoid biosynthetic pathway that generates bioactive molecules has been studied for over a decade. However, understanding of transcriptional regulators that control cannabinoid synthesis is fairly limited. The primary site of cannabinoid biosynthesis is glandular trichomes that form on female flowers.

Vital signs monitoring at home using the pulse oximeter utilizing analog sensors on a mobile device

The research project will develop key algorithms that enable pulse oximetry, on a smartphone, to be used effectively as a device for monitoring the function of heart and respiratory system at home. LGTmedical has developed a pulse oximeter that utilizes inexpensive clinical sensors driven by software running on a smartphone, sending the driving signals through the audio port. This technology already operates with clinical accuracy for uses in spot-check monitoring of blood oxygen and heart rate.

Design and Development of a High-Resolution Sensory System for Detection of Biogenic Signals - Year Two

The main focus of this project will be conducting research and developing novel sensory systems to be used in various agricultural environments. The proposed research project also involves development of interpretation algorithms and data-mining software. Ecoation Innovative Solutions (EIS) developed a technology that monitor and interpret different plant signal patterns.

Application of Variable Speed Drives for Improved Grinding Energy Efficiency

The research program is aimed at developing operating systems that enable grinding mill speeds to be controlled in responses to variations in ore properties. Although there are studies that show speed control can improve productivity and significantly reduce energy requirements, mines presently used fixed speed systems for their ball and tower mills. With development of new variable speed drive systems that can retrofitted to the fixed speed systems, there is an opportunity for mines to introduce the technology for their operation.

Passive optical remote sensing of channel bathymetry for monitoring of large river morphodynamics

Air photos and satellite images offer a comprehensive perspective on rivers that can be useful for the study and management of aquatic ecosystems. In particular, water depths can be determined remotely by relating image properties (color, brightness, etc.) to depths measured through fieldwork. However, this reliance on field data for calibration of the depth/image relationship requires costly, sometimes dangerous fieldwork and means the methods cannot be applied to data sources without associated field-measured depths.

Enteroids and enteroid derived monolayer cultures: Using primary intestinal epithelial cell cultures to define the mechanisms underlying epithelial intrinsic innate defenses

Using growth media available from Stemcell technologies, along with our own tools and techniques, we can isolate and grow intestinal stem cells from mice or human patient donors into enteroid cultures. Enteroids are 3D cell cultures that replicate many of the structures and types of cells found in the intestinal lining. We propose to work with Stemcell technologies to continue to develop their growth media for enteroid culture and apply these new media and techniques to further or understanding of how these cells help the body defend against infection.

University-to-Work Transition Project

Research on university graduates’ University-to-Work transition (UWT) is sharply polarized between two discourses: the smooth transition narrative and the crisis narrative. Proponents of the smooth transition narrative such as universities are reporting high-rates of student satisfaction, skill transferability as well as early-career earnings consistent with those of 1970s and 1980s’s graduates. At the same, the crisis narrative is pointing at rampant underemployment, a loose School-to-Work transition structure and a blunt lack of high-skilled technical labour.

Optimization and validation of carbon nanofiber catalyst supports in fuel cell stack

Motivated by the urgent need for clean and sustainable source of energy we propose to develop structurally and chemically controllable fuel cell catalyst layers based on ultrafine nanocomposite carbon fibre catalyst support. Manufacturing parameters will be controlled and optimized to investigate the effect of microstructure on key performance factors. Ultimately, the knowledge gained from this study will pave the way to building more efficient fuel cells. Current phase of the project involves validating our design by in-situ testing.

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