Modelling the movement of water through a hydropower station is an important tool for understanding this very complex behaviour, where water is pushed and pulled through long tunnels and spinning turbines, resulting in a vast range of pressures and speeds. There are generally two types of models: 1-dimensional (1D) models, which are simple and cost-effective, but do not provide adequate detail for the more complex features in the power station. The second type is 3-dimensional (3D) models, which are very detailed but cost both time and money.
The continuously increasing demand for wireless access, driven by the increasing requirements of our connected society, is pushing current wireless cellular communication systems to the limits of their capacity. The objective of this project is to continue the successful collaboration with our industry partner (Telus Corporation) to further contribute to the evolution of current generation wireless cellular communication systems (4G LTE) along with the development of next generation wireless cellular communication systems (5G) to meet current and future requirements of our connected society.
The NSERC Strategic Network for Smart Applications on Virtual Infrastructures is a five-year partnership between Canadian industry, universities, researchers, research and education (R&E) networks, and high performance computing centres to investigate the design of future application platforms that will deliver software applications of greater capability and intelligence.
Programming of long-term digital memory storage devices is currently not an optimised process. This is due to the fact that the exact physical mechanisms that allow for a data bit to be reliably stored and read are not well understood. As a result, in order to produce high quality, long-lasting, reliable memory cells, the manufacturer must perform extensive testing and
iterative modifications on each generation of products. Our project aims to develop a software model that simulates the physics and chemistry of memory device structures on an atomic level.
Membrane proteins such as ion channels, transporters or G-protein coupled receptors (GPCRs) are excellent but difficult drug targets involved in a large number of life-threatening diseases and conditions. These proteins, over-expressed and essential for disease onset and progression, are naturally targeted by toxins from venomous organisms. During evolution, these toxins have been optimized to efficiently target physiologically-relevant proteins involved in ion channel opening or closure, thus incapacitating the prey or defending against predators.
Signaling through the Eph family of cell surface receptors is crucial for embryonic development and the maintenance of adult tissues. Given the central role of the 14 Eph receptors in controlling cell fate, it is not surprising that they also play a central role in oncogenesis and other pathological conditions. However, the signaling mechanisms of Eph receptors are extremely complex, and developing an effective therapeutic intervention for a particular disease requires a comprehensive understanding of Eph function.
Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect in 2D/3D systems and will move to preclinical/clinical trials upon successful in vitro validation.
Proteins can exist in two forms: left-handed (L) or right-handed (D); however, for indeterminate reasons life on this planet only uses the L-form. When studied in more detail, both protein forms possess identical physiochemical and biological properties. Yet, D-proteins show minimal proteolytic degradation and fail to elicit immune responses in animals, due to their unnatural arrangement for recognition in biological systems. Accordingly, the proposed project seeks to develop synthetic D-proteins as biopharmaceutical molecules.
As the Canadian population is aging, more and more Canadians will show cognitive decline. Aging and certain types of
neurological disorders is often associated with deficits in executive functions: goal maintenance, planning, task
switching and attention. These functions are critical for the maintenance of functional independence. Few validated
rehabilitation approaches for these types of deficits exist. One rehabilitation approach, Goal Management Training
(GMT), has shown promise. In its standard implementation, GMT is led in small groups.
In Canada, people with diabetes are 20x more likely to have an amputation of their lower limb than the general population. Having a diabetic foot ulcer (DFU) increases the risk of amputation by 50%. Early assessment and treatment of a patients DFU can prevent amputation, but patients with diabetes often lose sensation in their limbs, and may not even realize they have a DFU. There are currently no easily accessible early warning tools for DFUs. To address this need, we have invented a non-invasive device for DFU assessment, and are now optimizing it for use in patients at St.