Development of dual antibody therapies for cancer

Cancer is a devastating disease defined by genetic changes that result in the activation of proteins that encourage cell growth or prevent cell death. Modern oncology aims to specifically target these tumour-promoting proteins, which has the secondary benefit of leaving normal cells unharmed, unlike chemotherapy. Recently, a number of drugs that specifically block tumour-promoting proteins have been produced, yet the results are underwhelming: most targeted therapies show an initial benefit, followed by the development of resistance.

My Wellness Journey: A Health Promotion Study for Children and Youth with Disabilities

The purpose of this project is to support the development of wellness-focused interventions, including weight management, mental health and social well-being for children with intellectual and developmental disabilities (IDD). To date, the focus of health promotion interventions have primarily focused on typically developing children and adolescents, rather than those with IDD.

Creating a platform to collect / publish / analyze / control communication data streams

The NSERC Strategic Network for Smart Applications on Virtual Infrastructures is a five-year partnership between Canadian industry, universities, researchers, research and education  (R&E) networks, and high performance computing centres to investigate the design of future application platforms that will deliver software applications of greater capability and intelligence.

Optimizing Output Control of the MyndMove Functional Electrical Stimulator

The intern will undertake research and development activities related to a novel functional electrical stimulation (FES) device called the MyndMove stimulator. Activities are intended to improve the electrical output of the MyndMove to deliver controlled and painless electrical stimulation to patients for a variety of applications, such as mobility, pain management and treatment of pressure sores. This research project should help to make MyndMove therapy more effective and easier to deliver, increasing patient access and improving rehabilitation outcomes.

Development of Cell-Based Functional Assays to Accelerate Commercialization and Therapeutic Application of Recombinant Antibodies

Antibodies are the fastest growing segment of the pharmaceutical market, and with modern engineering technologies antibodies can be programmed to target devastating diseases. Within the immune system, antibodies fight invading bacteria and viruses. High-quality synthetic antibodies directed to disease-related targets have immense therapeutic potential. Development of cell-based assays to enable rapid identification of functionally active antibodies is a critical step in the commercialization process.

Development and Delivery of Inhibitors for Viral Pathogenic Deubiquitinases

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to evade the immune system by interfering with host ubiquitin-dependent processes.

In Vivo Reprogramming of Spiral Ganglion Glial Cells into Primary Auditory Neurons

Sensorineural hearing loss involves damage to hair cells, the sensory transducers of the auditory system, and/or the auditory neurons that transmit this information to the brain. Once these cells are lost the body does not naturally regenerate them. Elsewhere it has been shown that cells of one type may be converted into another cell type. This project involves using viral expression of select transcription factors in the spiral ganglion to convert resident cells into new auditory neurons to restore hearing.

Crystal Orientation-Wetting Property Relationships for Cerium Oxide

Improving the durability of superhydrophobic surfaces is of significant interest in the surface engineering community. We have recently developed a novel superhydrophobic coating with a hard nanocrystalline nickel matrix and embedded hydrophobic polytetrafluoroethylene (PTFE) particles. To further improve the mechanical robustness of the non-wetting coating, the soft polymeric PTFE particles were replaced with hard, hydrophobic cerium oxide ceramic particles. However, the intrinsic hydrophobic properties of cerium oxide are not well understood.

Self-driving wheelchair rolls out at University of Toronto

Working under the direction of Professor Jonathan Kelly, Xinyi is helping to extend leading-edge technology that makes it possible for the wheelchair to navigate and drive itself.

Tailoring Mesenchymal Stromal Cell Therapy to Rescue Marginal DCD Livers for Transplantation

Today 25% of patients listed for liver transplantation die waiting for a liver to become available. The donor organ pool could be expanded by rescuing the 50% of livers donated after cardiac death (DCD) that are discarded due to the injury caused by prolonged periods of warm ischemia during organ retrieval. Mesenchymal Stromal Cells (MSC) reduce inflammation and promote tissue repair.