Firms meet legally established accounting rules by including notes in financial statements that essentially hide key information in plain sight. That is, they contain information necessary to understand the statements, but due to the volume of notes and arcane language may be uninterpretable by even lawyers. However, these notes may be interpretable by a software application. For example, the notes in the Enron case were found to be decipherable by a human being, but only after substantial effort.
Field Programmable Gate Arrays (FPGAs) are integrated circuits that can be programmed after manufacturing. It has applications in a wide variety of fields, from cryptography to machine learning. Computer Aided Design (CAD) tools are used to automate the process of programming FPGAs. Routing is a component of CAD that attempts to find an optimal design of wiring to connect logic blocks on an FPGA. Although it is an old problem, there are many interesting problems to solve and it is an active area of current research.
Unmanned aerial vehicles (also known as drones) constitute a sector of the Canadian aerospace industry that is growing very rapidly. Because there is a broad range of applications for drones, there is also a wide variety of drone configurations. This, coupled with the small size of drones, leads to a scarcity of convenient rules-of-thumb and guidelines for the design of drone structures. In addition, because of the small size of drones, small reductions in the mass of a drone structure lead to relatively large proportional increases in drone payload.
Depression is a disabling condition affecting millions of people. Some of the symptoms of depression make it impossible for people to function in their daily lives. People experience significant levels of memory, thinking, planning and other cognitive symptoms that impair their abilities to go to work, school and take care of themselves and family. What is unclear is how and to what extent does this type of impairment lead to real world disability, and whether or not these levels of impairment exist in a broad range of people with varying levels of depressive symptomology.
Glioblastoma (GBM) is the most common primary adult brain tumor, characterized by extensive cellular and genetic heterogeneity. Even with surgery, standard chemotherapy, and radiation, tumor recurrence and patient relapse are inevitable with a median survival rate of
Periodontitis is a polymicrobial infectious and inflammatory disease that can lead to destruction of supporting structures of teeth. Although pathogenesis of periodontitis includes genetic and environmental factors, oral microbial biofilm elicits an inflammatory host reaction. Improvement in patients with periodontitis relies mainly on elimination or at least control of periodontal pathogens. The aim of this study is to investigate the activity of antibacterial-antifungal mouth rinses on growth and virulence properties of planktonic/biofilm cells of specific periodontal pathogens.
A recently developed technology called CRISPR/Cas9 allows scientists to quickly and precisely edit DNA in living cells and is about to revolutionize molecular biology and genetics. The success of CRISPR/Cas9 is based on its ease of use, effectiveness and cost efficiency. Our aim is to explore a variant of this technology, CRISPR/Cpf1, for its application in genomic engineering and potential benefits.
Patients who suffer from severe burns require immediate wound closure to ensure survival and facilitate healing. The current gold standard in surgical practice is the use of split-surface autographs, allographs, or skin substitutes, but limitation range from the lack of layered tissue organization, the potential for immunological rejection, and the need for high quantities of donated tissue.
The NSERC Strategic Network for Smart Applications on Virtual Infrastructures is a five-year partnership between Canadian industry, universities, researchers, research and education (R&E) networks, and high performance computing centres to investigate the design of future application platforms that will deliver software applications of greater capability and intelligence.