Modeling the Removal of Mine-impacted Water Species Using Freezing Technologies Focused on Frazil Ice Formation

The development of environment-friendly freezing technologies to contaminated water is a potential solution for water treatment in regions with cold weather conditions and vulnerable to anthropogenic impact. The results of laboratory tests fulfilled by Core Geoscience Services Inc. on the removal of mine-impacted water species through ice formation along with other publicly available data will form a basis for the next stage of research comprising quantitative analysis and mathematical modelling.

Identifying and validating rational combinatorial therapies for treatment-refractory Glioblastoma

Glioblastoma (GBM), the most common and deadly form of primary brain cancer in adults. After diagnosis, GBM patients undergo standard therapy, including surgery, chemotherapy and radiation therapy. Unfortunately, disease relapse is inevitable and patients face a median survival of less than 15 months. A small population of tumor cells, known as brain tumor initiating cells (BTICs), have been shown to resist standard therapy and lead to relapse. Using a multi-pronged approach, we are developing novel and rational combinatorial therapies against treatment-resistant GBM BTICs.

Developing surfactant–nanoparticle systems for enhanced oil recovery

There has been a growing interest in the application of nanotechnology for enhanced oil recovery (EOR). Nanoparticles possess unique physical and chemical properties due to their small size. In addition, their surface coating can be easily tailored for a particular EOR application. The proposed research will develop surfactant-coated nanoparticles as an additive. These nanoparticles will increase the recovery of residual oil in unconventional reservoirs found in Saskatchewan. Silica nanoparticles will be coated with zwitterionic surfactants.

Liquid biopsy for the discovery of new methods of cancer diagnosis and new treatment strategies

Despite the improvements in cancer diagnostic and treatment, cancer is still a leading cause of death in Canada with 30% of all deaths. Some cancers, like pancreatic cancer (PC), still have poor survival rates due to the lack of early diagnosis and good prognostics markers. The Atlantic Cancer Research Institute (ACRI) has developed a proprietary technology to capture extracellular vesicles (EVs) from various biofluids with the goal to deliver precision medicine solutions through liquid biopsy technologies.

Development of a human immortalized FSHD cell line to study the epigenetic targeting of DUX4 to treat FSHD

Facioscapulohumeral muscular dystrophy (FSHD) is a debilitating disease resulting from the loss of skeletal muscles mainly in the face, shoulder blades and upper arms. FSHD results from expression of the protein DUX4
which causes skeletal muscle cell death and therefore loss of muscles. This project aims to immortalize isolated skeletal muscle cells from patients with FSHD and produce long-lived cells that can be used to screen
pharmaceutical compounds for their ability to inhibit the expression of DUX4 and therefore treat FSHD.

Characterizing the sources of methane, CO2, and hydrogen sulphide presence during thermal oil recovery operations

Greenhouse gas (GHG) emissions contribute to a global warming trend associated with climate change. Methane is a potent GHG with a global warming potential 25 times that of Carbon Dioxide over a 100-year period. Gas migration /Surface casing vent flows from subsurface to surface is a well-known issue; however, characterizing the source zone(s) for stray gases from production, injection, and observation wells is an ongoing challenge in the oil/gas industry.

Systematic evaluation and optimization of immune-targeting modalities for GBM and brain metastases.

The Centre for the Commercialization of Antibodies and Biologics (CCAB) is working with Empirica Therapeutics (Empirica), a Canadian start-up company focused on developing data-driven treatments for cancer, to address the unmet medical needs of glioblastoma (GBM), the most common adult malignant primary brain tumor. Current therapies are only partly effective, with frequent relapse and poor patient survival, which correlates with the presence of CD133+ brain tumor-initiating cells that are also implicated in treatment-resistant GBM. By partnering with Dr.

Somatic cell reprogramming as a tool for the conservation of genetic resources from endangered species

Conservation of endangered species has become increasingly urgent. This is evident given the rate of species extinction by 100 to 1000-fold, and global biodiversity has decreased. With current climate changes, these concerns will only grow. Assisted reproductive technologies can play a vitalrole in endangered species conservation. Many approaches are currently being utilized or explored, including animal cloning. Unfortunately, cloned animals are not genetically pure and therefore, are not valuable for use in breeding programs.

Simultaneous Analysis of Endocannabinoids with Mass Spectrometry Methods in Human Serum using Point-of-care Collection Devices

Endocannabinoids are compounds produced by the human body that bind to and activate cannabinoid receptors. There are two major endocannabinoids: anandamide (AEA) and 2-arachidonoylglycerol (2-AG). Both play a role in regulating the firing of brain cells in the nervous system and attenuating immune system responses. As such, the endocannabinoid system is implicated in several clinically relevant processes including appetite regulation, pain management, fertility, and beyond.

Integrated post-harvest wash systems for fruit and vegetable decontamination for reducing water usage and decrease emission of disinfectant byproducts in wastewater streams

The Canadian Food Guide has recommended an increase in fresh produce in the daily diet. Although the nutritional benefits of fresh produce are well established there are continuing food safety issues, high wastage and water consumption. To enhance safety and shelf-life it is common practice to pass produce through a post-harvest wash using chlorine as sanitizer. Chlorine is reactive and forms disinfection byproducts from constituents released from produce during washing. The byproducts are considered environmental pollutants but also has low antimicrobial activity.

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