Over the last decade, multiple pandemic events have highlighted the vulnerability of the world to existing and emerging infectious threats. Currently, COVID19 has infected >4M people resulting in >300K deaths. Although there are candidate drugs in development, the projected term until an effective COVID therapy or vaccine is available is projected to between 1-2 years. COVID19 marks the third coronavirus outbreak (preceded by SARS and MERS) within the last 20 years and suggests spillover of animal to human coronavirus will occur again.
The SARS-CoV-2 outbreak, which started in Dec. 2019, has so far not been contained due to unpreparedness and unsuccessful development of antiviral drugs against SARS-CoV-2. In response to this pandemic, we propose strategies for the development of novel antiviral agents against a number of known viral targets using in-silico modeling and laboratory testing to rapidly identify and validate their efficiency in blocking viral functions.
As of May 1st, 2020, over 3.2 million cases of COVID-19 have been confirmed, resulting in over 233,000 deaths globally. This project aims to provide an alternative vaccine for the prevention and treatment COVID-19 in high risk individuals, mainly the elderly and immunocompromised, who do not respond well to tranditional vaccination.
The goal of this study will be to characterize a SARS-CoV2 antigen and the formulated drug product that will contain SARS-CoV2 antigen and a squalene-based adjuvant under tight timeline to release the material for COVID-19 vaccine clinical trials.
This project will be studying the relationship of Green Anacondas with their surroundings by describing the ways Anacondas use their habitats and how these behaviours change throughout the year. We will be using a technology called “radio telemetry” to follow Anacondas in order to observe them and collect information. Drone and Satellite imagery will be used to describe the Anacondas territories and habitats. Anacondas are important “top” predators of rainforest ecosystems and are also valuable in conservation land management through eco-tourism.
Narwhals are an iconic ice-associated species that are seasonably distributed across much of the Canadian archipelago that are also of immense cultural importance to the Inuit First Nations. While narwhal are highly adapted to their sea-ice environments, their susceptibility to the stresses of a changing climate and increased human activity in the area are a major concern.
The research project will find optimal conditions for instrument-free, fast, and sensitive/specific detection of pathogen (COVID-19). The project is composed in two units(IU), each module within IU is offering independent technical solution for the current bottleneck in diagnostics industry. The first module is temperature-based denaturation of biological sample, coupled with nucleic acid-based detection (IU1). The second module is composed of specific amplification of biomarker for intended target/s, (instrument free) and the last module is colorimetric detection of amplified biomarker.
BOLD-100 is a promising new clinical stage therapeutic, originally developed for the use as a cancer treatment. The mechanism of action for BOLD-100 suggests that this therapeutic might also protect against infections with viruses, including coronaviruses like SARS-COV-19. The purpose of this project is to test the antiviral efficacy of BOLD-100 against SARS·COV-19 in 20 and 30 cell culture models, and then investigate the mechanism of action. These results will help define BOLD-100 as an antiviral treatment and support clinical investigations into BOLD-100 for the treatment of COVID-19.
Solar cells are an incredible source of renewable energy. As with all technologies, though, they should be cheap,
easy to adopt, and smart. Dye-Sensitized Solar cells are solar cells that are not only highly effective at creating
energy from the sun but are also capable of being adopted into homes in new and unique ways. We are developing
a method of converting existing windows into solar cells. Throug this technology a window would still act as a
window, except it would also be capable of harvesting energy from the sun and powering a home.
The presence of newly identified or emerging contaminants (ECs) in bodies of water is of growing concern for the health and safety of humans and the environment. These undesirable organic compounds range from endocrine disruptors and pharmaceuticals to personal care products, pesticides, and fertilizers. The existing wastewater treatment plants lack adequate infrastructure for removing these pollutants. Synthetic biology, or the engineering of biological systems for useful applications, is well-suited to address the challenge of ECs.