Development of advanced electrochemical techniques for the production of graphene-based nano-materials from graphite

Graphene is considered a strategic nanomaterial for the development of clean technologies due to its unique properties. According to Allied Market Research, the global graphene market was valued at US $91.3 million in 2019, and is projected to grow to US $1.4 billion by 2027 at a compound annual growth rate (CAGR) of 40.2% from 2020 to 2027. Currently, there are no clean and cost-effective technologies available for the mass production of graphene. ZEN Graphene Solutions Ltd.

In Vacuo Glycation of Insulin

More than 2 million Canadians suffer from diabetes, a disease associated with the body’s inability to produce or effectively use insulin. The high blood sugar levels associated with diabetes can lead to serious complications such as vision loss, kidney failure, cardiovascular problems, and amputation. Therefore, diabetes patients are treated with insulin, with the aim of achieving tight control over their blood sugar levels.

Green Solvents for Isopropyl Alcohol Replacement

Due to the increased demand for isopropyl alcohol industrial clients are turning to replacements for industrial uses. Producing an alternative for isopropyl alcohol for specific industrial applications is now a sought-after target. Creating an environmentally friendly alternative is desired since volatile chemicals used in industrial applications are a major contributor to smog formation.

Effects of cannabinoids on ACE2-rich cells

The COVID-19 pandemic is caused by SARS-CoV2 coronavirus. This virus which infect cells that are vital in human organs leading to multiple diseases in need of timely medical treatment. There is a great need in search of inhibitors to block such viral infections as a means for disease prevention and/or treatment. Cannabinoids, such as cannabidiol (CBD), and high-CBD producing plant species of the Cannabis genus will be tested for the inhibition effects.

Long-Term Prevention of Catheter Infections Using Chemical Coatings - Year two

Urinary tract infections caused by indwelling catheters (CAUTIs) employed for the treatment of urinary flow are very common. Almost 100 million of these devices are sold on an annual basis with around 25% of these being marketed in the USA. In addition to the cost of catheters and their insertion, hospital treatment of CAUITs runs into the hundreds of millions of dollars every year.

Porous polymeric extraction devices for fast, convenient, and portable monitoring of organic contaminants in marine environments

Organic contaminants enter the marine environment through atmospheric transport, runoff into waterways, or directed disposal into the ocean. They are prone to long-range, bioaccumulation and can have adverse effects on human health and the environment. In this project, a simple and convenient extraction device developed for analysis of organic pollutants will be examined for various types of environmental monitoring such as active and passive sampling. Our proof-of-concept studies have shown the that these devices provide simple, high throughput, reliable and green analyses.

Plasmonic Nanoparticle Enhanced Seawater Desalination

To combat the growing need for accessible freshwater sources across the globe, new technologies that don’t rely on fossil fuels are ideal. Additionally, these technologies should be easily implemented in the developing communities that need them most for lower cost than the current options. The purification of seawater, also known as desalination is a highly attractive method due to the large amount of easily accessible saltwater, though current methods are highly fossil-fuel dependent.

Porous materials as a filtration method for ship exhaust

The Canadian government has vowed to reduce their pollutant emissions by 2030 in order to curb the effects of climate change. This means that shipping companies must make strides to reduce their overall emissions. This project will use novel sponge-like frameworks, called metal-organic frameworks (MOFs), to remove environmentally toxic pollutants from exhaust gas. The materials currently being utilized for pollutant gas removal (e.g.. limestone) are often are very minimally active by weight, this is not the case for MOFs.

Production and Purification of Titanium-45 for Positron Emission Tomography Imaging

Nuclear medical imaging relies on the detection of radiation that is emitted from the body after a radioactive isotope that has been fused to a disease targeting molecule (aka radiotracer) is administered to the patient. For example, positron emission tomography (PET) scans can be used to image and diagnose disease in the body with extremely high resolution and sensitivity. The radioactive isotope titanium-45 has the ideal properties to be incorporated into a nuclear imaging agent for PET scans.

Discovery of ligands for disrupting the SARS-CoV-2 interactome with human proteins using multipronged genetically encoded technologies

The proposed project will accelerate the drug development capabilities of 48Hour Discovery INC (48HD) to find high affinity drug candidates for treatment of COVID. The deliverable for this project will be high potential new drug candidates from 48HD’s drug discovery pipeline for COVID and other targets using unique molecular libraries of 48HD. The libraries are stable and resilient to stimulated gastrointestinal conditions and thus, the discovery platform will provide potentially oral and bioavailable therapeutics.

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