Effects of various compounds on central nervous system neurons as potential therapeutics against epilepsy

Xenon has developed isoform selective blockers of the sodium channels that are expressed in CNS neurons with the intent of developing them for therapeutic use, especially epilepsy. The primary goal of this research project is to determine the activity of compounds on CNS neurons. Until now, all characterization has been done with heterologously expressed channels. Until recently, a major impediment to such studies is the heterogenous nature of CNS neurons, so that a large number of studies need to be conducted for a complete characterization.

The effects of X-Act Compression garments technology on muscle fatigue, active and passive joint torque and performance

There are many compression garment products on the market claiming to improve some aspect of performance, however their claims are not validated with empirical data. In fact, current literature regarding the benefits of compression garments on cardiovascular and biomechanical performance is controversial; with many results suggesting non-significant or even negative effects provided by the compression garment.

Somatostatin signalling and diabetes

The prevalence of diabetes is growing rapidly and currently, over 60 million people worldwide use insulin treatment to manage their diabetes. However, insulin treatment can result in hypoglycemia or low blood sugar levels. To date only retroactive treatments are available to treat hypoglycemia, which affects an individual’s quality of life and increases the likelihood of recurring bouts of hypoglycemia as well as development of cardiovascular or renal disease.

Understanding changes in corticospinal excitability due to chronic resistance training and fatigue

The proposed research will allow us to determine how the human central nervous system (i.e. brain and spinal cord) functions to produce different intensities of muscle contractions with and without fatigue. We will use a variety of stimulation technics to determine how active the brain and spinal cord are during the arm contractions. We do not currently have a detailed understanding of how the brain and spinal work together during force production.

The Impact of Renovations in Long Term Care Living Spaces on Residents with Dementia, their Families and the Staff that Care for Them

Riverview Health Centre (RHC) plans to renovate their special care units and grounds, which accommodate 60 residents with intermediate and advanced stages of dementia. The main purpose of this study is to examine the effects of the renovations on residents, family and staff using a multi-methods research approach and a multi-disciplinary team of researchers (i.e., architecture, sociology, kinesiology, clinical psychology, pharmacy, nutrition, nursing, and health sciences).

Improved Care for High Risk Arthritis Patients

Arthritis affects 4.6 million Canadians and the demand for timely and effective care is critical to better patient outcomes and cost effectiveness. The research projects will identify better models of care delivery for:
1) at risk patients with obesity who may require knee and/or hip replacement surgery or require conservative medical treatment in place of surgery; and,
2) for inflammatory disease (IA) patients who require rapid medical intervention to limit disease progression and symptoms.
This research will use data modeling tools for such patients to analyze the risk and need for surgery.

Implementation and Evaluation of an Integrated Chiropractic Service for Musculoskeletal Conditions into the Canadian Forces Health Service

Low back pain is a leading cause of disability worldwide. The Canadian Armed Forces (CF) has a greater incidence of LBP than the general population. LBP is responsible for a large proportion of medical releases in the CF with many cases resulting in lifelong pain and disability. Improved early access to evidence-based care could help prevent chronicity and recurrences, and reduce health care costs. The purpose of this project is to implement and evaluate a new inter-disciplinary, patient-centred health care service that includes chiropractic services for the management of LBP in the CF.

The Recess Project

Our goal is to continue to provide the solution to the problems that elementary schools are facing across Ontario. To re-define the existing culture of recess by providing healthy role models, options and equipment and advocating for spaces more conducive to play. Our research team is currently the only one in Canada dedicated to research on recess.

Appropriate Neuromuscular Rolling Intensities and Applications

Prior research has shown that rolling muscles can increase flexibility without performance decreases. These studies have used a variety of rolling pressures (intensities). It is not known whether higher or lower rolling pressures are better for improving flexibility. Thus one of the studies will examine different pressures of rolling on flexibility and muscle performance. On the other hand, it is not known whether the rolling effects are improved when combined with stretching. It is also not known what the duration of these effects might be.

Looking at the Physical and Psychosocial Outcomes of an After-School Physical Activity Intervention for Children with Congenital Heart Disease

The research intern will be working with Sportball to offer one of their multi-sport after-school programs to children who are living with serious heart defects. Physical activity has many health benefits for children, and after-school programs are an effective way to increase daily physical activity levels. Children living with heart disease are a vulnerable group who don’t regularly participate in physical activity, putting them at risk of developing chronic diseases later in life.

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