The effect of Granzyme B on photoaging

Aging is a complex, time-dependent process caused by decreased ability of the body to respond to environmental stress. In the case of skin aging, most of the associated changes are the result of sun exposure or ‘photoaging’. As the average age of the western population increases, there has been a substantial increase in interest in studying age related diseases and the causes of photoaging along with combating its effects in order to improve overall skin health and appearance.

Growing Up With Cerebral Palsy: Transitioning from Childhood to Adolescence in the Healthcare System

Children living with NDDs are often dependent on their parents and healthcare providers. As these children reach adolescence and prepare to transition from the pediatric to the adult health care system many issues affecting their autonomy are currently not being addressed. In addition to feature articles, sidebar articles with multimedia components will further examine these social and ethical challenges. Additionally, monthly articles about NDD science and related social and legal issues will be produced. Work will appear in The Vancouver Sun, in print and online versions.

QU02 MRI: a new window on mitochondrial dysfunction in Alzheimer's disease

This project seeks to develop new methods for imaging oxidative and vascular function in the brain. The methods under development are based on widely available MRI hardware, which will make them feasible for use in future clinical drug trials, an application that is of interest to the partner organization CQDM. Before the approach is ready for commercial application, a number of methodological issues must be addressed to achieve optimal sensitivity, specificity, and tolerability in patients.

Role of ROS regulation by Hace1 in modulating “stemness” versus differentiation of stem cells

The Sorensen laboratory-based Childhood Cancer Research Program is specifically focused on elucidating the genetic and biological determinants of the metastatic process in childhood cancer. Metastatic disease remains the single most dominant driver of adverse outcome in most childhood cancers, particularly in childhood sarcomas. Cancer stem cells, malignant cells that share many characteristics with normal stem cells, have been implicated to have a central role in the metastatic process.

Investigation of immunological mechanisms of peptide immunotherapy

Although early clinical trials have been positive, peptide vaccine mechanism of action (how tolerance is induced) is unknown. The primary objective of these studies is to identify changes in gene expression and cytokine expression that are correlated with vaccine treatment. These changes could provide insight to mechanisms of action and may reveal potential genetic biomarkers that could then be validated for use in clinical development of peptide vaccines, and also the treatment of allergic disease.

Development of a Rapid Point of Care test for Food & Water Safety

The project involves the development of a rapid detection test kit that will enable food processors to measure the absence or presence of potentially harmful pathogenic organisms prior to shipment to the general trade. The interns’ main objectives will be to dramatically reduce the assessment time for the tester- currently ranging from 4 to 5 days- to an elapsed time of minutes. The kit will benefit the food processor to reduce microbial risk and potential cost from a recall, while the consumer will have safer foods.

The Energetics of Forearm Crutch Gait: The impact of a dynamic shock absorber

Many people who use crutches for their short-term or long-term mobility experience problems associated with crutch gait such as overuse injuries to the arms, discomfort, and fatigue. Forearm crutches enable people to be mobile and live independent and active lives, however many individuals experience fatigue associated with the increased energy demands of this type of gait. A new type of crutch has been developed with a shock-absorbing component that aims to alleviate impact on the joints.

Metabolic Lipid Abnormalities in Prediabetes and Insulin Resistance

Type 2 diabetes is characterized by insulin resistance and has been associated with increased lipids (fat) in the blood (hyperlipidemia). Our research focuses on regulation of blood lipid levels by controlling both intestinal and liver fat (lipid/lipoprotein) metabolism. We have previously shown in our laboratory that a naturally occurring hormone called glucagon-like peptide-1 (GLP-1) can lower intestinal lipoprotein production.

Diagnostic screening for conscious awareness in brain injury and disease: Visual component

Since the mid 1970s, medical personnel have used the Glasgow Coma Scale (GCS) as an important tool to rate and describe levels of consciousness. This scale is rudimentary and subjective, often resulting in misdiagnoses in cases where people lack the capacity to communicate. In some unfortunate situations, severe neurological damage can render people unable to move. Inevitably, these people are deemed vegetative when in actuality; many are simply ‘locked in’. Family members and professionals alike are left wondering…are they in there?

Understanding Stress Signaling in Childhood Cancers: ROS signaling pathways

The Sorensen laboratory-based Childhood Cancer Research Program is specifically focused on elucidating the genetic and biological determinants of the metastatic process in childhood cancer. Metastatic disease remains the single most dominant driver of adverse outcome in most childhood cancers, particularly in childhood sarcomas. There are two basic strategies in the program for studying metastatic disease in childhood cancers. The first is to focus on cell stress signaling.

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