The Healthy Body Scorecard: A new health screening tool for Canadian

Building off of the original Healthy Bodies Scorecard project, this research aims to test the newly developed Healthy Body Scorecard tool and provide evidence of its usefulness. We will distribute the draft of the scorecard along with a feedback questionnaire for health care practitioners (HCP’s) targeting those who work with typically developing children as well as those with experience working with children with disabilities.

Vein depth estimation with Christie VeinViewer

The proposed project is aimed at developing image and signal processing algorithms to enable the Christie VeinViewer® device to determine approximate depth of veins. This is a challenging research project due to the limited amount of information available and real-time fast processing required. The VeinViewer® uses a single infrared wavelength and a CMOS camera to detect superficial veins.

Pharmacodynamic distribution of docetaxel andcabazitaxel in prostate cancer xenografts, and evaluation of pantoprazole to enhance their activity

Chemotherapy drugs target and kill rapidly-dividing cells located closest to blood vessels, but do not penetrate deep into the tumor. Limited drug distribution in tumors is an important cause of drug resistance. A method to increase tumor drug delivery and combat resistance is the subject of this proposal. To counteract chemotherapy resistance, the use of an ulcer medication (pantoprazole) is being investigated. The objective of this proposal is to determine the drug effect of cabazitaxel using biomarkers that indicate where in the tumor a drug is working.

Pharmacodynamic distribution of docetaxel andcabazitaxel in prostate cancer xenografts, and evaluation of pantoprazole to enhance their activity

Chemotherapy drugs target and kill rapidly-dividing cells located closest to blood vessels, but do not penetrate deep into the tumor. Limited drug distribution in tumors is an important cause of drug resistance. A method to increase tumor drug delivery and combat resistance is the subject of this proposal. To counteract chemotherapy resistance, the use of an ulcer medication (pantoprazole) is being investigated. The objective of this proposal is to determine the drug effect of cabazitaxel using biomarkers that indicate where in the tumor a drug is working.

Characterization of a novel humanized monoclonal antibody specific to KAL 006: Impact on lymphatic metastasis in cancer

Cancer cells can travel to distant sites through the lymphatic system; this system is similar to a network of pipes within the body that carries fluids and cells to all organs. The metastatic spread of cancer cells through this network is one of the reasons why this disease is so difficult to stop. We are working with Kalgene Pharmaceuticals to test a new compound that can impact the lymphatic system. The hope is to block this network and thus stop metastatic spread thereby improving patient survival.

Technologies for Living Independently: A Technology Case Study on Remote Patient Monitoring

The population age distribution is undergoing an “inversion” and the dependency ratio, i.e., the proportion of older adults who are not working over the number of adults who are working, is increasing. This has an effect on a society’s ability to deliver community-care services and the underlying national economic capacity to pay for their needs. Advances in ICT (information and communications technologies) promise to provide support for affordable systems of care that enable human resources to be used more effectively.

The effect of Granzyme B on photoaging

Aging is a complex, time-dependent process caused by decreased ability of the body to respond to environmental stress. In the case of skin aging, most of the associated changes are the result of sun exposure or ‘photoaging’. As the average age of the western population increases, there has been a substantial increase in interest in studying age related diseases and the causes of photoaging along with combating its effects in order to improve overall skin health and appearance.

Growing Up With Cerebral Palsy: Transitioning from Childhood to Adolescence in the Healthcare System

Children living with NDDs are often dependent on their parents and healthcare providers. As these children reach adolescence and prepare to transition from the pediatric to the adult health care system many issues affecting their autonomy are currently not being addressed. In addition to feature articles, sidebar articles with multimedia components will further examine these social and ethical challenges. Additionally, monthly articles about NDD science and related social and legal issues will be produced. Work will appear in The Vancouver Sun, in print and online versions.

QU02 MRI: a new window on mitochondrial dysfunction in Alzheimer's disease

This project seeks to develop new methods for imaging oxidative and vascular function in the brain. The methods under development are based on widely available MRI hardware, which will make them feasible for use in future clinical drug trials, an application that is of interest to the partner organization CQDM. Before the approach is ready for commercial application, a number of methodological issues must be addressed to achieve optimal sensitivity, specificity, and tolerability in patients.

Role of ROS regulation by Hace1 in modulating “stemness” versus differentiation of stem cells

The Sorensen laboratory-based Childhood Cancer Research Program is specifically focused on elucidating the genetic and biological determinants of the metastatic process in childhood cancer. Metastatic disease remains the single most dominant driver of adverse outcome in most childhood cancers, particularly in childhood sarcomas. Cancer stem cells, malignant cells that share many characteristics with normal stem cells, have been implicated to have a central role in the metastatic process.

Pages