Advanced Data Science Research for Social Good II

Municipal governments and urban centres across Canada are being inundated with data—data that have potential to improve public service. Despite this, local governments do not have enough data expertise to extract insight from these overwhelming datasets. Simultaneously, high-quality personnel (HQP) in the domains of data science and urban analytics lack opportunities to work closely with local government to address this gap.

Exploring the Impact of Housing-based Overdose Prevention Interventions on People who use Drugs in Vancouver - Year two

Canada is amid an opioid epidemic, with governments declaring overdose public health emergency. Drug-related overdose mortality in British Columbia reached a record high in 2017, with over 1400 deaths. In response, novel overdose prevention interventions (OPI) have been implemented, including: overdose prevention sites in which people can inject drugs under supervision; and, naloxone training and distribution (a medication that blocks the effects of opioids during an overdose).

The Voices of Children and Youth: Community Injury Prevention through Visual Storytelling and Intervention (VOICES) in First Nations communities

The Voices research project aims to build injury prevention capacity within the First Nation community of Akwesasne (near Cornwall, ON) and among researchers.

Development of Coxsackievirus B3 as an Oncolytic Virus for KRAS-Mutant Lung Cancer Treatment

In Canada, lung cancer is the leading cause of cancer-related deaths for both sexes. Non-small-cell lung cancer (NSCLC) constitutes ~85% of lung cancer cases. Mutations in the KRAS and EGFR genes are two most common oncogenic drivers for NSCLC and responsible for ~30% and ~15% of NSCLCs, respectively. Unlike the EGFR-mutant type, KRAS-mutant NSCLC is currently undruggable and associated with poor prognosis. Our lab has recently demonstrated that Coxsackievirus B3 (CVB3) is a potent oncolytic virus against KRAS-mutant NSCLC.

Development and trial of evaluative frameworks for inclusive employment programs

The Canadian Panel on Labour Market Opportunities for Persons with Disabilities (2012) found that 795,000 persons with disabilities in Canada are unemployed, even though their disabilities do not prevent them from working, and almost half have some form of post-secondary education. The exclusion of this section of the Canadian workforce is not only a key health and social issue, but also an economic and labour market one. Governments and private sector organizations have tried to address this disconnect in labour market engagement through a range of policies and supported employment programs.

A novel home cage testing environment for frontal cortical neuronal recording in marmosets - Year two

Marmosets are a valuable model for investigating the neural bases of behaviour and cognition, and there has been a substantial increase in marmoset use in translational neuroscience research over the last few years. A comfortable environment is critical for marmoset neurophysiological testing. At Rogue Research the fellow will be involved in developing a unique apparatus that attaches to the monkeys’ homecage and will permit automated neurophysiological testing using a touchscreen, reward systems, variety of sensors, and physiological setups for recording brain activity during research tasks.

Transitioning from Print to Interactive Digital Publishing

PUBLIC is an innovative print periodical with a 25 year history exploring the intersection between art, design, technology and contemporary culture. This Mitacs fellowship will develop the journal’s open access interactive web platform, PUBLIC:PORTAL, using information visualization and design to showcase the journal’s cutting-edge collaborative and cross-disciplinary work. This project designs and tests graphical user interfaces and information visualization strategies in order to investigate the ways that abstract and complex information can be conveyed through intuitive design.

The Cost-Benefit Analysis of Capacity Building Initiative for Rural Community Health Research in Northern Newfoundland and Coastal Labrador (Rural 360 Project)

Faculty Development Programs (FDPs) are widely well-established through the academic medical centers (AMCs); however, little attention has been paid to rural and remote physicians (RRPs), despite their critical role in addressing the priority health concerns of the communities. In response to this, 6for6 and Rural 360 projects have been introduced by the Memorial University of Newfoundland.
One of the key questions for researchers is how to evaluate the economic impact/value of these projects.

CRISPR-Cas9-based screening and engineering of novel biologics to target the vulnerabilities of primary and recurrent glioblastoma

Glioblastoma (GBM) is the most common primary adult brain tumor. Even with surgery, standard chemotherapy, and radiation, tumor recurrence and patient relapse are inevitable with a median survival rate of

Assessment of Myocardial Perfusion Enhancement Associated with Current Treatments for Ischemic Heart Disease Using Positron Emission Tomography

Efficient pumping function of heart depends on receiving oxygen and nutrients through heart’s specific blood vessels called coronaries. In case of coronary stenosis (e.g. plaques formation on their inner walls), the heart muscle cannot function normally and may be permanently damaged. Three treatment strategies are broadly available that include medications, coronary stent placement and coronary bypass graft surgery. However, the efficacy of either treatment in restoring blood perfusion to the heart muscle is not clearly quantified.