Perpetual Nomads: an exploration of indigenous narratives and imagery through contemporary and experimental mediums

The goal of the Perpetual Nomads project is to make illustration depicting many indigenous and environmental issues through traditional art media and digital media. The team will be exploring the viability of creating Mixed Reality interactive experiences to increase the awareness, empathy, egalitarianism and environmental concern in users through these illustrated narratives. Since people use new technologies and traditional arts for expressing themselves in so many ways, its crucial for youth to be exposed to powerful ideas relating to consciousness, sustainability and connectivity.

Oncolytic HSV-1 (oHSV-1) for treatment of prostate cancer

This project is to use genetic engineered “cold-sore” virus to treat prostate cancer. The virus is engineered to reduce its toxicity to normal tissues but can specifically attack and kill tumour cells. Meanwhile, the virus releases a group of anti-tumour immune stimulating factors to activate immune system to eliminate prostate tumour. This project will use a unique prostate tumour mouse model to test the virus.

Effects of dietary glutathione precursors on cellular redox and mitochondrial efficiency in adults consuming a defined hypocaloric diet (Optifast-900; Nestlé Canada)

The aim of the proposed research is to investigate the cellular mechanistic effects of supplementation with a hypocaloric meal replacement product (Optifast-900; Nestlé Canada) containing cysteine and glycine, which are amino acid precursors of the antioxidant glutathione. Impaired cellular glutathione redox normally occurs with aging and metabolic disorders, however, this study will focus on a population in which we have previously observed impaired muscle cellular glutathione redox and slow weight loss during the exclusive dietary consumption of Optifast-900.

Physiological assessment of cochlear and auditory nerve integrity in children suspected of auditory processing disorder

The American Speech-Language-Hearing Association (ASHA) recommends to include electrophysiological measures in their auditory processing disorder (APD) assessment battery. But few audiologist include electrophysiological assessment due to lack of evidence. There is strong evidence of auditory brainstem abnormality in these children. However, very less is understood about stimulus processing within the cochlea, auditory brainstem coding in noise (ipsilateral) and the thalmocortical functioning in APD children.

Using multivariate deep-learning algorithms for automatic quality control of high-resolution MRI

NeuroRx is an imaging contract research organization (CRO) specialized in the central nervous system (CNS) that utilizes state-of-the-art digital image processing techniques to produce accurate and precise outcome measures for clinical trials of drugs in development. Prior to analysis, all scans must pass Quality Control (QC). The goal of this project will be to incorporate advanced computer algorithms to automatically classify the quality of high-resolution structural brain Magnetic Resonance Images. The advanced computer algorithms will include deep learning algorithms.

The role of integrins in stretch-induced activation of TGF-?1 and pulmonary fibrosis

Fibroproliferative disorders are the leading cause of morbidity and mortality worldwide. A large group of interstitial lung diseases (ILD) can cause progressive scarring of lung tissues, affecting the ability to breathe. Idiopathic Pulmonary Fibrosis (IPF) is one of the major forms of ILD and is characterized by a progressive decline in lung function. Although the pathogenesis of IPF is not completely understood, work from our group and others suggest that transforming growth factor beta 1 (TGF-?1) is involved in the fibrogenic process.

Transitional REM Sleep Brain Connectomes and Seizure Susceptibility

Seizures are rare while dreaming in rapid eye movement (REM) sleep. New research, however, suggests seizures may rebound during unstable REM sleep. This may be due to brain wiring (“connectivity”) since a highly connected brain is more prone to seizures, and connectivity changes from wakefulness to sleep. Brainwave tracings (“EEG”) can generate connectivity maps (“connectomes”) but adequate connectome resolution requires many EEG electrodes (“high density EEG”). This study uses high density EEG to examine brain connectomes and seizure susceptibility in unstable REM sleep.

Towards personalized surgical spine reconstruction post tumour resection

We aim to develop tools to assess patient outcomes following treatment and removal of bone metastases. We will identify markers for enhanced patient outcomes, so as to predict which patients may benefit from more aggressive treatments to better their quality of life. We also aim to use 3D printed bone implants to help in the treatment of patients with bone metastasis. These implants will serve as a local reservoir for the anticancer drugs that will improve bone regeneration while also preventing tumor recurrence.

Towards Detection of Subclinical Joint Bleeds in Hemophiliacs: Advanced Imaging

This project aims to assess how the use of the novel “ultra-short echo-time” (UTE) MR imaging technology can “add value to” conventional MRI for detection and quantification of blood products in hemophilic joints. We will test this novel technology in joints of hemophilic patients with different stages of arthropathy presenting with blood products at different stages of degradation as compared with existing MRI sequences.

Evaluating the effectiveness of real time image filtering in multi-platform live broadcasting and interactive VR installations as means for artistic expression

There are several platforms that allow users to share real time video with the public. However, these platforms lack the tools that would allow creative professionals to create artistic video compositions extemporaneously. Our prior research assessed the potential for artistic expression within live video broadcasting by developing and integrating new creative tools within the Generate platform, a mobile tool for dynamic artistic video compositions. Behavioral analysis provided the information to determine the effectiveness and relevance of video art in an online real time nature.

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