Importance clinique de pathogènes entériques dans la diarrhée péri-sevrage des porcelets et impact sur la contamination des carcasses par des pathogènes alimentaires

Parmi les différentes étapes de production, le sevrage des porcelets est un moment crucial ayant un impact important sur la productivité et la rentabilité des entreprises. Cette période représente en effet un risque élevée pour la transmission de maladies infectieuses à cause du stress qu’elle engendre et à cause de l'immaturité du système immunitaire au cours des premières semaines de vie. Les cas de diarrhées peuvent rapidement prendre des proportions épidémiques et avoir des conséquences dramatiques à l’échelle du troupeau.

Determining the half-life of prophylaxis treatment using population pharmacokinetics

Hemophilia is a rare blood coagulation disorder caused by a deficiency or deformity in one of 12 primary clotting factors. Hemophiliacs experience insufficient healing and prolonged bleeding either from trauma or unprompted bleeding. We are able to maintain a level of the deficient factors in a patient through direct and immediate infusion of a drug into the blood. To determine the frequency of injections and the appropriate dosage, we need to consider how long a drug will stay in a child’s body.

High resolution PET imaging systems for small animal imaging

There is an increasing demand for high resolution multimodality imaging of research animals, such as mice and rats, to allow non-invasive monitoring of disease models and therapeutic interventions. This project focuses on the development of a new positron emission tomography (PET) imaging system that can be operated inside a magnetic resonance imaging (MRI) system. Once complete, this system will allow simultaneous high resolution PET/MRI imaging of research animals.

Development of qPCR tests for the assessment of water quality

Despite many recent advances in biotechnology, the methods for monitoring water quality remain largely unchanged for the past century. We will use next-generation DNA sequencing technology to guide the design of novel DNA-based tests to improve sensitivity and specificity of water quality testing.

Gut-localized expression of IL-10 for the treatment and/or prevention of peanut allergy

We will evaluate treatments for peanut allergy, the most severe and persistent form of food allergy. The proposed interventions are based on targeted delivery of interleukin-10 (IL-10) to the intestine. IL-10 is a protein that is known to be a potent regulator of the immune system. enGene has developed EG-10, a novel, state-of-the-art technology that can effectively induce a robust and transient production of interleukin-10 in the intestine, i.e., the site where food absorption occurs and food allergy is initiated.

Development and Piloting of Nationally Leading Curricula for Job Coach Training in Autism Spectrum Disorder

This project will develop, pilot and evaluate a training program for job coaches and other related support providers to person with Autism Spectrum Disorder, using several sequential steps, as follows. (1) We will conduct an environmental scan of existing job coach training curriculum. (2) We will present this information in focus groups across Alberta that include adults with autism, family members, job coahces, employes, and other key stakeholders that support the autism community and understand the role of, and potential issues for, job coaches in autism.

Cytotoxicity analysis of novel monoclonal antibodies targeting SSAT-1

Cancer is one of the leading causes of death worldwide with approximately 8 million deaths in 2010. Most cancer treatments lack specificity and affect the whole body, with toxic effects on both cancerous and normal cells. The cytotoxic effect of a new therapy developed by Biomark Technologies, Inc. targeting cancer cells will be assessed. Biomark Technologies Inc. has found that the expression levels of the gene coding for the protein SSAT 1 is upregulated in cancer cells.

Investigating the role of probiotics in cell death and intestinalbarrier integrity

Our gastro-intestinal tract is colonized by billions of microorganisms that constitute the intestinal flora or microbiota. These microorganisms, primarily bacteria, are required for our development and physiology; however, changes in the "normal" composition of the microbiota, referred to as dysbiosis, have been linked to chronic inflammatory diseases in humans. Currently, a major research effort is to understand what these commensal bacteria are, how they maintain health, and how their dysregulation causes disease.

Quantitative Digital Pathology Algorithm for an Automated Cancer Slide Imaging System

Digital Pathology provides a great reliable source for cancer diagnosis; however, this relatively new technique lacks an appropriate method of regulation and standardization. As a result the information obtained from cancer imaging system might suffer from inconsistency of the results (repeatability and reproducibility issues). Working with the BC Cancer Research Center, Logipath Medical Inc. has developed a number of quantitative pathology systems some of which have been spun off to commercial entities.

Identification of non-coding RNA involved in castrate-resistant prostate cancer

Prostate cancer (PCa) is the most common cancer affecting Western men. Unfortunately, treatment for advanced prostate cancer is strictly palliative and lethal treatment-resistant disease eventually arises (castrate-resistant prostate cancer (CRPC)). Interrogating the genome of pre and post CRPC allows for the identification genetic differences that drive progression and resistance, representing candidate therapeutic targets and molecular biomarkers.